Staci N Keller
Overview
Explore the profile of Staci N Keller including associated specialties, affiliations and a list of published articles.
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13
Citations
486
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0
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Recent Articles
1.
Maines L, Keller S, Smith R, Schrecengost R, Smith C
Cancers (Basel)
. 2024 May;
16(9).
PMID: 38730731
Neuroblastoma (NB), the most common cancer in infants and the most common solid tumor outside the brain in children, grows aggressively and responds poorly to current therapies. We have identified...
2.
Maines L, Keller S, Smith R, Green C, Smith C
Int J Mol Sci
. 2024 Feb;
25(4).
PMID: 38396999
Fibrosis is a chronic pathology resulting from excessive deposition of extracellular matrix components that leads to the loss of tissue function. Pulmonary fibrosis can follow a variety of diverse insults...
3.
Maines L, Keller S, Smith C
Int J Mol Sci
. 2023 Dec;
24(23).
PMID: 38069222
Antibody-based cancer drugs that target the checkpoint proteins CTLA-4, PD-1 and PD-L1 provide marked improvement in some patients with deadly diseases such as lung cancer and melanoma. However, most patients...
4.
Maines L, Green C, Keller S, Fitzpatrick L, Smith C
Int J Nephrol Renovasc Dis
. 2022 Nov;
15:323-334.
PMID: 36420520
Introduction: Acute kidney injury (AKI) is a common multifactorial adverse effect of surgery, circulatory obstruction, sepsis or drug/toxin exposure that often results in morbidity and mortality. Sphingolipid metabolism is a...
5.
Maines L, Schrecengost R, Zhuang Y, Keller S, Smith R, Green C, et al.
Int J Mol Sci
. 2022 Nov;
23(21).
PMID: 36361977
Exposure to ionizing radiation (IR) is a lingering threat from accidental or terroristic nuclear events, but is also widely used in cancer therapy. In both cases, host inflammatory responses to...
6.
Smith C, Maines L, Keller S, Ben-Yair V, Fathi R, Plasse T, et al.
Drug Des Devel Ther
. 2022 Jul;
16:2199-2211.
PMID: 35855741
The Covid-19 pandemic driven by the SARS-CoV-2 virus continues to exert extensive humanitarian and economic stress across the world. Although antivirals active against mild disease have been identified recently, new...
7.
Schrecengost R, Green C, Zhuang Y, Keller S, Smith R, Maines L, et al.
J Pharmacol Exp Ther
. 2018 Feb;
365(1):107-116.
PMID: 29434052
Glycogen synthase kinase-3s (GSK3 and GSK3) are constitutively active protein kinases that target over 100 substrates, incorporate into numerous protein complexes, and regulate such vital cellular functions as proliferation, apoptosis,...
8.
Schrecengost R, Keller S, Schiewer M, Knudsen K, Smith C
Mol Cancer Res
. 2015 Aug;
13(12):1591-601.
PMID: 26271487
Unlabelled: The bioactive sphingolipid sphingosine-1-phosphate (S1P) drives several hallmark processes of cancer, making the enzymes that synthesize S1P, that is, sphingosine kinase 1 and 2 (SK1 and SK2), important molecular...
9.
Gangjee A, Namjoshi O, Keller S, Smith C
Bioorg Med Chem
. 2011 Jun;
19(14):4355-65.
PMID: 21680190
Gangjee et al. recently reported a novel series of 2-amino-4-methyl-5-phenylethyl substituted-7-benzyl-pyrrolo[2,3-d]pyrimidines, some of which exhibited two digit nanomolar antitumor and antimitotic activity and were not subject to P-glycoprotein (Pgp) or...
10.
French K, Zhuang Y, Maines L, Gao P, Wang W, Beljanski V, et al.
J Pharmacol Exp Ther
. 2010 Jan;
333(1):129-39.
PMID: 20061445
Sphingolipid-metabolizing enzymes control the dynamic balance of the cellular levels of important bioactive lipids, including the apoptotic compound ceramide and the proliferative compound sphingosine 1-phosphate (S1P). Many growth factors and...