Srinivas Somarowthu
Overview
Explore the profile of Srinivas Somarowthu including associated specialties, affiliations and a list of published articles.
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23
Citations
540
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Recent Articles
1.
Oh M, Kadam R, Charania Z, Somarowthu S
bioRxiv
. 2025 Feb;
PMID: 39975023
Long non-coding RNAs (lncRNAs) play key roles in a range of biological processes and disease progression. Despite their functional significance and therapeutic potential, lncRNAs' mechanisms of action remain understudied. One...
2.
Yankey A, Oh M, Lee B, Desai T, Somarowthu S
Sci Rep
. 2024 Aug;
14(1):19384.
PMID: 39169000
Long non-coding RNAs (lncRNAs) play key roles in cellular pathways and disease progression, yet their molecular mechanisms remain largely understudied. The lncRNA lncTCF7 has been shown to promote tumor progression...
3.
Sarfaraz N, Somarowthu S, Bouchard M
J Med Virol
. 2022 Aug;
95(1):e28058.
PMID: 35946066
Hepatitis B Virus (HBV) infections remain a major global health burden with an estimated 296 million people living with a chronic infection and 884,000 HBV-related deaths annually. Notably, patients with...
4.
Manigrasso J, Chillon I, Genna V, Vidossich P, Somarowthu S, Pyle A, et al.
Nat Commun
. 2022 Jan;
13(1):1.
PMID: 34983933
No abstract available.
5.
Yankey A, Clark S, Owens M, Somarowthu S
Methods Mol Biol
. 2021 Aug;
2372:93-110.
PMID: 34417746
Long noncoding RNAs (lncRNAs) are now accepted as key players in diverse cellular functions, yet the structure-function relationships of these novel RNAs remain mostly unknown. Homogenous purification of lncRNAs is...
6.
Mazina O, Somarowthu S, Kadyrova L, Baranovskiy A, Tahirov T, Kadyrov F, et al.
J Biol Chem
. 2020 Aug;
295(41):14203-14213.
PMID: 32796030
Replication protein A (RPA), a major eukaryotic ssDNA-binding protein, is essential for all metabolic processes that involve ssDNA, including DNA replication, repair, and damage signaling. To perform its functions, RPA...
7.
Manigrasso J, Chillon I, Genna V, Vidossich P, Somarowthu S, Pyle A, et al.
Nat Commun
. 2020 Jun;
11(1):2837.
PMID: 32503992
Group II introns are ubiquitous self-splicing ribozymes and retrotransposable elements evolutionarily and chemically related to the eukaryotic spliceosome, with potential applications as gene-editing tools. Recent biochemical and structural data have...
8.
Shenoda B, Ramanathan S, Gupta R, Tian Y, Jean-Toussaint R, Alexander G, et al.
Cell Mol Life Sci
. 2020 Mar;
78(1):299-316.
PMID: 32193609
Biological sex influences inflammatory response, as there is a greater incidence of acute inflammation in men and chronic inflammation in women. Here, we report that acute inflammation is attenuated by...
9.
Owens M, Clark S, Yankey A, Somarowthu S
Int J Mol Sci
. 2019 Sep;
20(19).
PMID: 31561429
Long non-coding RNA (lncRNA) biology is a rapidly growing area of study. Thousands of lncRNAs are implicated as key players in cellular pathways and cancer biology. However, the structure-function relationships...
10.
Tavares R, Pyle A, Somarowthu S
J Mol Biol
. 2019 Mar;
431(8):1592-1603.
PMID: 30890332
The existence of evolutionary conservation in base pairing is strong evidence for functional elements of RNA structure, although available tools for rigorous identification of structural conservation are limited. R-scape is...