Michal Legiewicz
Overview
Explore the profile of Michal Legiewicz including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
14
Citations
447
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Bishop D, Caproni L, Gowrishankar K, Legiewicz M, Karbowniczek K, Tite J, et al.
Mol Ther Methods Clin Dev
. 2020 Feb;
17:359-368.
PMID: 32071928
CD19-specific chimeric antigen receptor (CAR19) T cells, generated using viral vectors, are an efficacious but costly treatment for B cell malignancies. The nonviral transposon system provides a simple and inexpensive...
2.
Chillon I, Marcia M, Legiewicz M, Liu F, Somarowthu S, Pyle A
Methods Enzymol
. 2015 Jun;
558:3-37.
PMID: 26068736
The purification and analysis of long noncoding RNAs (lncRNAs) in vitro is a challenge, particularly if one wants to preserve elements of functional structure. Here, we describe a method for...
3.
Somarowthu S, Legiewicz M, Chillon I, Marcia M, Liu F, Pyle A
Mol Cell
. 2015 Apr;
58(2):353-61.
PMID: 25866246
Long noncoding RNAs (lncRNAs) have recently emerged as key players in fundamental cellular processes and diseases, but their functions are poorly understood. HOTAIR is a 2,148-nt-long lncRNA molecule involved in...
4.
Somarowthu S, Legiewicz M, Keating K, Pyle A
Nucleic Acids Res
. 2013 Nov;
42(3):1947-58.
PMID: 24203709
It has become apparent that much of cellular metabolism is controlled by large well-folded noncoding RNA molecules. In addition to crystallographic approaches, computational methods are needed for visualizing the 3D...
5.
Purzycka K, Legiewicz M, Matsuda E, Eizentstat L, Lusvarghi S, Saha A, et al.
Nucleic Acids Res
. 2012 Oct;
41(1):463-73.
PMID: 23093595
Ty1, a long terminal repeat retrotransposon of Saccharomyces, is structurally and functionally related to retroviruses. However, a differentiating aspect between these retroelements is the diversity of the replication strategies used...
6.
Bindewald E, Wendeler M, Legiewicz M, Bona M, Wang Y, Pritt M, et al.
RNA
. 2011 Jul;
17(9):1688-96.
PMID: 21752927
Selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) is a facile technique for quantitative analysis of RNA secondary structure. In general, low SHAPE signal values indicate Watson-Crick base-pairing, and high...
7.
Kenyon J, Tanner S, Legiewicz M, Phillip P, Rizvi T, Le Grice S, et al.
Nucleic Acids Res
. 2011 May;
39(15):6692-704.
PMID: 21546549
Feline immunodeficiency virus (FIV) infects many species of cat, and is related to HIV, causing a similar pathology. High-throughput selective 2' hydroxyl acylation analysed by primer extension (SHAPE), a technique...
8.
Legiewicz M, Zolotukhin A, Pilkington G, Purzycka K, Mitchell M, Uranishi H, et al.
J Biol Chem
. 2010 Oct;
285(53):42097-104.
PMID: 20978285
Retrovirus replication requires specialized transport mechanisms to export genomic mRNA from the nucleus to the cytoplasm of the infected cell. This regulation is mediated by a combination of viral and/or...
9.
Legiewicz M, Badorrek C, Turner K, Fabris D, Hamm T, Rekosh D, et al.
Proc Natl Acad Sci U S A
. 2008 Sep;
105(38):14365-70.
PMID: 18776047
Nuclear export of certain HIV-1 mRNAs requires an interaction between the viral Rev protein and the Rev response element (RRE), a structured element located in the Env region of its...
10.
Legiewicz M, Wichlacz A, Brzezicha B, Ciesiolka J
Nucleic Acids Res
. 2006 Mar;
34(4):1270-80.
PMID: 16513845
We have used the in vitro selection method to search for catalytically active variants of the antigenomic delta ribozyme with mutations in the regions that constitute the ribozyme active site:...