Srinath Krishnamurthy
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Explore the profile of Srinath Krishnamurthy including associated specialties, affiliations and a list of published articles.
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15
Citations
155
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Recent Articles
1.
Smets D, Tsirigotaki A, Smit J, Krishnamurthy S, Portaliou A, Vorobieva A, et al.
EMBO J
. 2022 Aug;
41(23):e111344.
PMID: 36031863
Secretory preproteins of the Sec pathway are targeted post-translationally and cross cellular membranes through translocases. During cytoplasmic transit, mature domains remain non-folded for translocase recognition/translocation. After translocation and signal peptide...
2.
Krishnamurthy S, Sardis M, Eleftheriadis N, Chatzi K, Smit J, Karathanou K, et al.
Cell Rep
. 2022 Feb;
38(6):110346.
PMID: 35139375
Protein machines undergo conformational motions to interact with and manipulate polymeric substrates. The Sec translocase promiscuously recognizes, becomes activated, and secretes >500 non-folded preprotein clients across bacterial cytoplasmic membranes. Here,...
3.
Claesen J, Krishnamurthy S, Lau A, Economou A
Anal Chem
. 2021 Nov;
93(49):16341-16349.
PMID: 34841860
With differential hydrogen/deuterium exchange, differences in the structure and dynamics of protein states can be studied. Detecting statistically significant differentially deuterated peptides is crucial to draw meaningful conclusions about the...
4.
Smit J, Krishnamurthy S, Srinivasu B, Parakra R, Karamanou S, Economou A
Anal Chem
. 2021 Sep;
93(38):12840-12847.
PMID: 34523340
Hydrogen-deuterium exchange mass spectrometry (HDX-MS) is a powerful technique to monitor protein intrinsic dynamics. The technique provides high-resolution information on how protein intrinsic dynamics are altered in response to biological...
5.
Krishnamurthy S, Eleftheriadis N, Karathanou K, Smit J, Portaliou A, Chatzi K, et al.
Structure
. 2021 Apr;
29(8):846-858.e7.
PMID: 33852897
The cytoplasmic ATPase SecA and the membrane-embedded SecYEG channel assemble to form the Sec translocase. How this interaction primes and catalytically activates the translocase remains unclear. We show that priming...
6.
De Geyter J, Portaliou A, Srinivasu B, Krishnamurthy S, Economou A, Karamanou S
EMBO Rep
. 2020 Apr;
21(6):e49054.
PMID: 32307852
Bacterial secretory preproteins are translocated across the inner membrane post-translationally by the SecYEG-SecA translocase. Mature domain features and signal peptides maintain preproteins in kinetically trapped, largely soluble, folding intermediates. Some...
7.
Tulsian N, Krishnamurthy S, Anand G
Biophys J
. 2017 Jun;
112(12):2552-2566.
PMID: 28636912
Spatiotemporal control of the cAMP signaling pathway is governed by both hormonal stimulation of cAMP generation by adenylyl cyclases (activation phase) and cAMP hydrolysis by phosphodiesterases (PDEs) (termination phase). The...
8.
Ali N, Ling N, Krishnamurthy S, Oakhill J, Scott J, Stapleton D, et al.
Sci Rep
. 2016 Dec;
6:39417.
PMID: 28000716
The heterotrimeric AMP-activated protein kinase (AMPK), consisting of α, β and γ subunits, is a stress-sensing enzyme that is activated by phosphorylation of its activation loop in response to increases...
9.
Chandramohan A, Krishnamurthy S, Larsson A, Nordlund P, Jansson A, Anand G
PLoS Comput Biol
. 2016 Jun;
12(6):e1004840.
PMID: 27253209
A key question in mapping dynamics of protein-ligand interactions is to distinguish changes at binding sites from those associated with long range conformational changes upon binding at distal sites. This...
10.
Krishnamurthy S, Tulsian N, Chandramohan A, Anand G
Biophys J
. 2015 Aug;
109(6):1251-63.
PMID: 26276689
The second messenger molecule cAMP regulates the activation phase of the cAMP signaling pathway through high-affinity interactions with the cytosolic cAMP receptor, the protein kinase A regulatory subunit (PKAR). Phosphodiesterases...