Nikhil Kumar Tulsian
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Explore the profile of Nikhil Kumar Tulsian including associated specialties, affiliations and a list of published articles.
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12
Citations
68
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Recent Articles
1.
Shankar S, Liu Y, Tulsian N, Low B, Lin Q, Sivaraman J
PNAS Nexus
. 2024 Dec;
3(12):pgae536.
PMID: 39703232
BCL2/adenovirus E1B 19-kDa protein-interacting protein 2 homolog (BNIP-H or Caytaxin), a pivotal adaptor protein that facilitates cerebellar cortex growth and synaptic transmission, is posttranslationally modified to regulate neuronal function. This...
2.
Tulsian N, Palur R, Qian X, Gu Y, DO Shunmuganathan B, Samsudin F, et al.
Nat Commun
. 2023 Nov;
14(1):6967.
PMID: 37907459
The changing landscape of SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies. The functional activity of neutralizing...
3.
Huang Q, Gavor E, Tulsian N, Fan J, Lin Q, Mok Y, et al.
Protein Sci
. 2023 Aug;
32(10):e4761.
PMID: 37593853
The pupal cuticle protein from Aedes aegypti (AaPC) inhibits dengue virus (DENV) infection; however, the underlying mechanism of this inhibition remains unknown. Here, we report that AaPC is an intrinsically...
4.
Singh S, Machida S, Tulsian N, Choong Y, Ng J, Shankar S, et al.
Adv Sci (Weinh)
. 2023 Aug;
10(27):e2207672.
PMID: 37537642
HACE1 is an ankyrin repeat (AKR) containing HECT-type E3 ubiquitin ligase that interacts with and ubiquitinates multiple substrates. While HACE1 is a well-known tumor suppressor, its structure and mode of...
5.
Bagga T, Tulsian N, Mok Y, Kini R, Sivaraman J
Cell Mol Life Sci
. 2022 Apr;
79(5):233.
PMID: 35397701
Tripartite motif (TRIM) E3 ligases target specific substrates, including viral proteins, for proteasomal degradation, and are thus essential regulators of the innate antiviral response. TRIM69 ubiquitinates the non-structural NS3 protein...
6.
Gavor E, Choong Y, Tulsian N, Nayak D, Idris F, Sivaraman H, et al.
Life Sci Alliance
. 2021 Nov;
5(1).
PMID: 34750241
Metallocarboxypeptidases play critical roles in the development of mosquitoes and influence pathogen/parasite infection of the mosquito midgut. Here, we report the crystal structure of procarboxypeptidase B1 (PCPBAe1), characterized its substrate...
7.
Ghosh M, Wang L, Huber R, Gao Y, Morgan L, Tulsian N, et al.
Structure
. 2018 Dec;
27(2):302-314.e4.
PMID: 30503779
Histidine kinases (HKs) funnel diverse environmental stimuli into a single autophosphorylation event at a conserved histidine residue. The HK EnvZ is a global sensor of osmolality and cellular acid pH....
8.
Tulsian N, Krishnamurthy S, Anand G
Biophys J
. 2017 Jun;
112(12):2552-2566.
PMID: 28636912
Spatiotemporal control of the cAMP signaling pathway is governed by both hormonal stimulation of cAMP generation by adenylyl cyclases (activation phase) and cAMP hydrolysis by phosphodiesterases (PDEs) (termination phase). The...
9.
Husain N, Tulsian N, Chien W, Suresh S, Anand G, Sivaraman J
Sci Rep
. 2016 Nov;
6:37061.
PMID: 27845431
Aminoglycosides are broad-spectrum antibiotics that bind to the 30S ribosomal subunit (30S) of bacteria and disrupt protein translation. NpmA, a structurally well-characterized methyltransferase identified in an E. coli clinical isolate,...
10.
Krishnamurthy S, Tulsian N, Chandramohan A, Anand G
Biophys J
. 2015 Aug;
109(6):1251-63.
PMID: 26276689
The second messenger molecule cAMP regulates the activation phase of the cAMP signaling pathway through high-affinity interactions with the cytosolic cAMP receptor, the protein kinase A regulatory subunit (PKAR). Phosphodiesterases...