Anastassios Economou
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Explore the profile of Anastassios Economou including associated specialties, affiliations and a list of published articles.
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95
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2173
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Recent Articles
1.
Hamed M, Busche T, Simoens K, Carpentier S, Kormanec J, Van Mellaert L, et al.
Microb Cell Fact
. 2024 Jan;
23(1):13.
PMID: 38183102
Background: S. lividans TK24 is a popular host for the production of small molecules and the secretion of heterologous protein. Within its large genome, twenty-nine non-essential clusters direct the biosynthesis...
2.
Rossi P, Xing Q, Bini E, Portaliou A, Clay M, Warren E, et al.
J Mol Biol
. 2023 Jun;
435(11):167954.
PMID: 37330284
The flagellum is a sophisticated nanomachine responsible for motility in Gram-negative bacteria. Flagellar assembly is a strictly choreographed process, in which the motor and export gate are formed first, followed...
3.
Bui T, De Zitter E, Moeyaert B, Pecqueur L, Srinivasu B, Economou A, et al.
Int J Biol Macromol
. 2023 Mar;
239:124179.
PMID: 36972828
Reversibly switchable monomeric Cherry (rsCherry) is a photoswitchable variant of the red fluorescent protein mCherry. We report that this protein gradually and irreversibly loses its red fluorescence in the dark...
4.
Bademosi A, Decet M, Kuenen S, Calatayud C, Swerts J, Gallego S, et al.
Neuron
. 2023 Feb;
111(9):1402-1422.e13.
PMID: 36827984
Neuronal activity causes use-dependent decline in protein function. However, it is unclear how this is coupled to local quality control mechanisms. We show in Drosophila that the endocytic protein Endophilin-A...
5.
Shapovalov G, Ritaine A, Essonghe N, de Ridder I, Ivanova H, Karamanou S, et al.
Explor Target Antitumor Ther
. 2022 Sep;
3(3):375-391.
PMID: 36045908
Aim: Inositol 1,4,5-trisphosphate receptor (IPR) is a ubiquitous calcium (Ca) channel involved in the regulation of cellular fate and motility. Its modulation by anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) plays...
6.
Smets D, Tsirigotaki A, Smit J, Krishnamurthy S, Portaliou A, Vorobieva A, et al.
EMBO J
. 2022 Aug;
41(23):e111344.
PMID: 36031863
Secretory preproteins of the Sec pathway are targeted post-translationally and cross cellular membranes through translocases. During cytoplasmic transit, mature domains remain non-folded for translocase recognition/translocation. After translocation and signal peptide...
7.
Smets D, Smit J, Xu Y, Karamanou S, Economou A
J Mol Biol
. 2022 Aug;
434(19):167790.
PMID: 35970402
Sec secretory proteins are distinguished from cytoplasmic ones by N-terminal signal peptides with multiple roles during post-translational translocation. They contribute to preprotein targeting to the translocase by slowing down folding,...
8.
Krishnamurthy S, Sardis M, Eleftheriadis N, Chatzi K, Smit J, Karathanou K, et al.
Cell Rep
. 2022 Feb;
38(6):110346.
PMID: 35139375
Protein machines undergo conformational motions to interact with and manipulate polymeric substrates. The Sec translocase promiscuously recognizes, becomes activated, and secretes >500 non-folded preprotein clients across bacterial cytoplasmic membranes. Here,...
9.
Gouridis G, Muthahari Y, de Boer M, Griffith D, Tsirigotaki A, Tassis K, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(49).
PMID: 34845009
Novel biophysical tools allow the structural dynamics of proteins and the regulation of such dynamics by binding partners to be explored in unprecedented detail. Although this has provided critical insights...
10.
Claesen J, Krishnamurthy S, Lau A, Economou A
Anal Chem
. 2021 Nov;
93(49):16341-16349.
PMID: 34841860
With differential hydrogen/deuterium exchange, differences in the structure and dynamics of protein states can be studied. Detecting statistically significant differentially deuterated peptides is crucial to draw meaningful conclusions about the...