Srilatha Sakamuru
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Explore the profile of Srilatha Sakamuru including associated specialties, affiliations and a list of published articles.
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63
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1520
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Recent Articles
1.
Ooka M, Zhao J, Zhang L, Huang R, Sakamuru S, TeKrony C, et al.
Environ Sci Technol
. 2025 Mar;
PMID: 40047063
Superfund sites are where soil, air, and water are polluted with hazardous materials. Individuals residing and working in these areas are often exposed to metals and other hazardous materials, leading...
2.
Parham F, Eccles K, Rider C, Sakamuru S, Xia M, Huang R, et al.
Toxicol Sci
. 2025 Feb;
PMID: 39972627
In this paper, we provide a proof of concept evaluating the utility of the U.S. Tox21 high-throughput screening approach to assess the hazard of chemical mixtures using two estrogen receptor...
3.
Lynch C, Margolis R, Niebler J, Travers J, Sakamuru S, Zhao T, et al.
Front Pharmacol
. 2024 Nov;
15:1448744.
PMID: 39508053
Pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor with a well-established role in regulating drug metabolism and clearance. Recent studies have shown that PXR is involved in cell proliferation,...
4.
Ooka M, Sakamuru S, Furlow J, Xia M
Curr Protoc
. 2024 Oct;
4(10):e70029.
PMID: 39403992
Estrogen receptor alpha (ERα) is a nuclear receptor that is expressed mainly in the breast, uterus, and ovary, among several other organs. ERα plays important roles in reproduction, mammary gland...
5.
Yang S, Zhang L, Khan K, Travers J, Huang R, Jovanovic V, et al.
Endocrinology
. 2024 Sep;
165(10).
PMID: 39254333
There has been an alarming trend toward earlier puberty in girls, suggesting the influence of an environmental factor(s). As the reactivation of the reproductive axis during puberty is thought to...
6.
Luo X, Xu T, Ngan D, Xia M, Zhao J, Sakamuru S, et al.
Toxicol Appl Pharmacol
. 2024 Sep;
492:117098.
PMID: 39251042
Exposure to various chemicals found in the environment and in the context of drug development can cause acute toxicity. To provide an alternative to in vivo animal toxicity testing, the...
7.
Sakamuru S, Ma D, Pierro J, Baker N, Kleinstreuer N, Cali J, et al.
Biotechnol J
. 2024 Jun;
19(6):e2300659.
PMID: 38863121
All-trans retinoic acid (atRA) is an endogenous ligand of the retinoic acid receptors, which heterodimerize with retinoid X receptors. AtRA is generated in tissues from vitamin A (retinol) metabolism to...
8.
Ooka M, Sakamuru S, Zhao J, Qu Y, Fang Y, Tao D, et al.
J Hazard Mater
. 2024 May;
473:134642.
PMID: 38776814
Per- and poly-fluoroalkyl substances (PFAS) are synthetic chemicals widely used in commercial products. PFAS are a global concern due to their persistence in the environment and extensive associations with adverse...
9.
Lynch C, Sakamuru S, Ooka M, Huang R, Klumpp-Thomas C, Shinn P, et al.
Annu Rev Pharmacol Toxicol
. 2023 Jul;
64:191-209.
PMID: 37506331
Traditionally, chemical toxicity is determined by in vivo animal studies, which are low throughput, expensive, and sometimes fail to predict compound toxicity in humans. Due to the increasing number of...
10.
Xu T, Li S, Li A, Zhao J, Sakamuru S, Huang W, et al.
J Chem Inf Model
. 2023 Apr;
63(8):2321-2330.
PMID: 37011147
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) play important roles in human neurodegenerative disorders such as Alzheimer's disease. In this study, machine learning methods were applied to develop quantitative structure-activity relationship models...