Srigokul Upadhyayula
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Explore the profile of Srigokul Upadhyayula including associated specialties, affiliations and a list of published articles.
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45
Citations
1402
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Recent Articles
21.
He K, Song E, Upadhyayula S, Dang S, Gaudin R, Skillern W, et al.
J Cell Biol
. 2020 Jan;
219(3).
PMID: 31962345
Clathrin-coated vesicles lose their clathrin lattice within seconds of pinching off, through the action of the Hsc70 "uncoating ATPase." The J- and PTEN-like domain-containing proteins, auxilin 1 (Aux1) and auxilin...
22.
Pascolutti R, Algisi V, Conte A, Raimondi A, Pasham M, Upadhyayula S, et al.
Cell Rep
. 2019 Jun;
27(10):3049-3061.e6.
PMID: 31167147
Adaptor protein 2 (AP2) is a major constituent of clathrin-coated pits (CCPs). Whether it is essential for all forms of clathrin-mediated endocytosis (CME) in mammalian cells is an open issue....
23.
Paulsen B, Mandal P, Frock R, Boyraz B, Yadav R, Upadhyayula S, et al.
Nat Biomed Eng
. 2019 Apr;
1(11):878-888.
PMID: 31015609
Gene disruption by clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) is highly efficient and relies on the error-prone non-homologous end-joining pathway. Conversely, precise gene editing requires homology-directed...
24.
Gao R, Asano S, Upadhyayula S, Pisarev I, Milkie D, Liu T, et al.
Science
. 2019 Jan;
363(6424).
PMID: 30655415
Optical and electron microscopy have made tremendous inroads toward understanding the complexity of the brain. However, optical microscopy offers insufficient resolution to reveal subcellular details, and electron microscopy lacks the...
25.
Reconstitution of Clathrin Coat Disassembly for Fluorescence Microscopy and Single-Molecule Analysis
Bocking T, Upadhyayula S, Rapoport I, Capraro B, Kirchhausen T
Methods Mol Biol
. 2018 Aug;
1847:121-146.
PMID: 30129014
The disassembly of the clathrin lattice surrounding coated vesicles is the obligatory last step in their life cycle. It is mediated by the coordinated recruitment of auxilin and Hsc70, an...
26.
Upadhyayula S, Nunez V, Espinoza E, Larsen J, Bao D, Shi D, et al.
Chem Sci
. 2018 Aug;
6(5):3269.
PMID: 30123451
[This corrects the article DOI: 10.1039/C4SC02881C.].
27.
Swinburne I, Mosaliganti K, Upadhyayula S, Liu T, Hildebrand D, Tsai T, et al.
Elife
. 2018 Jun;
7.
PMID: 29916365
The inner ear is a fluid-filled closed-epithelial structure whose function requires maintenance of an internal hydrostatic pressure and fluid composition. The endolymphatic sac (ES) is a dead-end epithelial tube connected...
28.
Liu T, Upadhyayula S, Milkie D, Singh V, Wang K, Swinburne I, et al.
Science
. 2018 Apr;
360(6386).
PMID: 29674564
True physiological imaging of subcellular dynamics requires studying cells within their parent organisms, where all the environmental cues that drive gene expression, and hence the phenotypes that we actually observe,...
29.
Upadhyayula S, Nunez V, Espinoza E, Larsen J, Bao D, Shi D, et al.
Chem Sci
. 2018 Feb;
6(4):2237-2251.
PMID: 29449923
Cyanine dyes are broadly used for fluorescence imaging and other photonic applications. 3,3'-Diethylthiacyanine (THIA) is a cyanine dye composed of two identical aromatic heterocyclic moieties linked with a single methine,...
30.
He K, Iii R, Upadhyayula S, Song E, Dang S, Capraro B, et al.
Nature
. 2017 Dec;
552(7685):410-414.
PMID: 29236694
Vesicular carriers transport proteins and lipids from one organelle to another, recognizing specific identifiers for the donor and acceptor membranes. Two important identifiers are phosphoinositides and GTP-bound GTPases, which provide...