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Srigokul Upadhyayula

Explore the profile of Srigokul Upadhyayula including associated specialties, affiliations and a list of published articles. Areas
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Articles 45
Citations 1402
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Recent Articles
11.
Bertaccini G, Casanellas I, Evans E, Nourse J, Dickinson G, Liu G, et al.
bioRxiv . 2024 Jan; PMID: 38187535
PIEZO1 is critical to numerous physiological processes, transducing diverse mechanical stimuli into electrical and chemical signals. Recent studies underscore the importance of visualizing endogenous PIEZO1 activity and localization to understand...
12.
Liu G, Ruan X, Milkie D, Gorlitz F, Mueller M, Hercule W, et al.
Sci Adv . 2023 Mar; 9(13):eade6623. PMID: 37000868
Lattice light sheet microscopy excels at the noninvasive imaging of three-dimensional (3D) dynamic processes at high spatiotemporal resolution within cells and developing embryos. Recently, several papers have called into question...
13.
Wong K, Li T, Fu T, Liu G, Lyu C, Kohani S, et al.
Elife . 2023 Mar; 12. PMID: 36975203
How does wiring specificity of neural maps emerge during development? Formation of the adult olfactory glomerular map begins with the patterning of projection neuron (PN) dendrites at the early pupal...
14.
Mondal C, Gacha-Garay M, Larkin K, Adikes R, Di Martino J, Chien C, et al.
Cell Rep . 2022 Sep; 40(12):111358. PMID: 36130489
Many breast cancer (BC) patients suffer from complications of metastatic disease. To form metastases, cancer cells must become migratory and coordinate both invasive and proliferative programs at distant organs. Here,...
15.
Sheu S, Upadhyayula S, Dupuy V, Pang S, Deng F, Wan J, et al.
Cell . 2022 Sep; 185(18):3390-3407.e18. PMID: 36055200
Chemical synapses between axons and dendrites mediate neuronal intercellular communication. Here, we describe a synapse between axons and primary cilia: the axo-ciliary synapse. Using enhanced focused ion beam-scanning electron microscopy...
16.
Jin M, Shirazinejad C, Wang B, Yan A, Schoneberg J, Upadhyayula S, et al.
Nat Commun . 2022 Jun; 13(1):3578. PMID: 35732852
Actin assembly facilitates vesicle formation in several trafficking pathways, including clathrin-mediated endocytosis (CME). Interestingly, actin does not assemble at all CME sites in mammalian cells. How actin networks are organized...
17.
Chou Y, Upadhyayula S, Houser J, He K, Skillern W, Scanavachi G, et al.
Dev Cell . 2021 Jun; 56(12):1786-1803.e9. PMID: 34129835
Nuclear envelope assembly during late mitosis includes rapid formation of several thousand complete nuclear pore complexes (NPCs). This efficient use of NPC components (nucleoporins or "NUPs") is essential for ensuring...
18.
Gao R, Yu C, Gao L, Piatkevich K, Neve R, Munro J, et al.
Nat Nanotechnol . 2021 Mar; 16(6):698-707. PMID: 33782587
Expansion microscopy (ExM) physically magnifies biological specimens to enable nanoscale-resolution imaging using conventional microscopes. Current ExM methods permeate specimens with free-radical-chain-growth-polymerized polyacrylate hydrogels, whose network structure limits the local isotropy...
19.
Salman M, Marsh G, Kusters I, Delince M, Di Caprio G, Upadhyayula S, et al.
Front Bioeng Biotechnol . 2020 Oct; 8:573775. PMID: 33117784
We describe here the design and implementation of an microvascular open model system using human brain microvascular endothelial cells. The design has several advantages over other traditional closed microfluidic platforms:...
20.
Ozawa M, Hiver S, Yamamoto T, Shibata T, Upadhyayula S, Mimori-Kiyosue Y, et al.
J Cell Biol . 2020 Sep; 219(10). PMID: 32886101
Collective migration of epithelial cells plays crucial roles in various biological processes such as cancer invasion. In migrating epithelial sheets, leader cells form lamellipodia to advance, and follower cells also...