Srigiridhar Kotamraju
Overview
Explore the profile of Srigiridhar Kotamraju including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
63
Citations
1724
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Sahoo S, Kumari S, Pulipaka S, Chandra Y, Kotamraju S
Mol Carcinog
. 2024 Aug;
63(12):2291-2304.
PMID: 39136605
Sirtuin 1 (SIRT1), a member of histone deacetylase III family, plays a pivotal role in mediating chemoresistance in several cancers, including breast cancer. However, the molecular mechanism by which the...
2.
Singuru G, Pulipaka S, Shaikh A, Sahoo S, Jangam A, Thennati R, et al.
J Mol Med (Berl)
. 2024 May;
102(7):927-945.
PMID: 38758435
The development and progression of hyperglycemia (HG) and HG-associated atherosclerosis are exacerbated by mitochondrial dysfunction due to dysregulated mitochondria-derived ROS generation. We recently synthesized a novel mitochondria-targeted esculetin (Mito-Esc) and...
3.
Pulipaka S, Chempon H, Singuru G, Sahoo S, Shaikh A, Kumari S, et al.
Mech Ageing Dev
. 2024 Mar;
219:111931.
PMID: 38554949
Impaired mitochondrial fatty acid β-oxidation (FAO) plays a role in the onset of several age-associated diseases, including atherosclerosis. In the current work, we investigated the efficacies of mitochondria-targeted esculetin (Mito-Esc)...
4.
Pulipaka S, Singuru G, Sahoo S, Shaikh A, Thennati R, Kotamraju S
Geroscience
. 2023 Dec;
46(2):2801.
PMID: 38146018
No abstract available.
5.
Pulipaka S, Singuru G, Sahoo S, Shaikh A, Thennati R, Kotamraju S
Geroscience
. 2023 Nov;
46(2):2391-2408.
PMID: 37968424
Atherosclerosis, in general, is an age-associated cardiovascular disease wherein a progressive decline in mitochondrial function due to aging majorly contributes to the disease development. Mitochondria-derived ROS due to dysregulated endothelial...
6.
Singuru G, Pulipaka S, Shaikh A, Andugulapati S, Thennati R, Kotamraju S
Int Immunopharmacol
. 2023 Oct;
124(Pt B):111070.
PMID: 37862737
Mitochondrial dysfunction due to deregulated production of mitochondria-derived ROS is implicated in the development and progression of non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH). Recently, we synthesized a...
7.
Neeli P, Sahoo S, Karnewar S, Singuru G, Pulipaka S, Annamaneni S, et al.
FEBS J
. 2022 Aug;
290(2):502-520.
PMID: 36017623
DOT1L, a specific H3K79 methyltransferase, has a tumour-promoting role in various cancers, including triple-negative breast cancer (TNBC). However, the molecular mechanism by which the deregulated DOT1L promotes cancer progression is...
8.
Karnewar S, Pulipaka S, Katta S, Panuganti D, Neeli P, Thennati R, et al.
Atherosclerosis
. 2022 Aug;
356:28-40.
PMID: 35961209
Background And Aims: Age is a dominant and independent risk factor for the development of atherosclerosis, a major cardiovascular disease, and if left untreated leads to myocardial infarction and death....
9.
Shaikh A, Neeli P, Singuru G, Panangipalli S, Banerjee R, Maddi S, et al.
Chem Commun (Camb)
. 2021 Nov;
57(92):12329-12332.
PMID: 34740232
Herein, we document a self-assembling octyl-TPP tagged esculetin (Mito-Esc) as functionally active and as a novel small molecule siRNA delivery vector. While Mito-Esc itself induces selective breast cancer cell death,...
10.
Kallepu S, Neeli P, Mallappa S, Nagendla N, Mudiam M, Mainkar P, et al.
ChemMedChem
. 2020 Sep;
15(19):1826-1833.
PMID: 32893968
Late-stage functionalization (LSF) aids drug discovery efforts by introducing functional groups onto C-H bonds on pre-existing skeletons. We adopted the LSF strategy to synthesize analogues of the abundantly available triterpenoid,...