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» Authors » Srideshikan Sargur Madabushi

Srideshikan Sargur Madabushi

Explore the profile of Srideshikan Sargur Madabushi including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 11
Citations 38
Followers 0
Related Specialties
Oncology
Radiology
Molecular Biology
Top 10 Co-Authors
Susanta K Hui
Jamison Brooks
Darren Zuro
Hemendra Ghimire
Paresh Vishwasrao
Jerry Froelich
Marcin Kortylewski
Ji Eun Lim
Guy Storme
Amandeep Salhotra
Published In
Front Oncol
Int J Radiat Oncol Biol Phys
IEEE Access
Methods Mol Biol
Haematologica
Affiliations
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Recent Articles
1.
Development of Proton Density Fat Fraction Micro-MRI for Non-Invasive Quantitative Assessment of Bone Marrow Changes with Age and Radiation in Mouse Models
Ghimire H, Malekzadeh M, Lim J, Madabushi S, Zampini M, Camacho A, et al.
bioRxiv . 2025 Jan; PMID: 39803423
Background/objectives: Bone marrow (BM) adipocytes are critical in progressing solid tumor metastases and hematological malignancies across pediatric to aging populations. Single-point biopsies remain the gold standard for monitoring BM diseases,...
2.
Thrombopoietin mimetic therapy alleviates radiation-induced bone marrow vascular injury in a bone marrow transplant mouse model
Ghimire H, Madabushi S, Vercellino J, Brooks J, Zuro D, Lim J, et al.
Front Oncol . 2024 Oct; 14:1414488. PMID: 39450249
Background: There is a need for therapies that can mitigate bone marrow dysfunction and organ toxicity that occur following myeloablative injury and reduced intensity conditioning regimens used in patients undergoing...
3.
Total marrow irradiation reduces organ damage and enhances tissue repair with the potential to increase the targeted dose of bone marrow in both young and old mice
Lim J, Madabushi S, Vishwasrao P, Song J, Abdelhamid A, Ghimire H, et al.
Front Oncol . 2022 Nov; 12:1045016. PMID: 36439420
Total body irradiation (TBI) is a commonly used conditioning regimen for hematopoietic stem cell transplant (HCT), but dose heterogeneity and long-term organ toxicity pose significant challenges. Total marrow irradiation (TMI),...
4.
Development and characterization of a preclinical total marrow irradiation conditioning-based bone marrow transplant model for sickle cell disease
Madabushi S, Fouda R, Ghimire H, Abdelhamid A, Lim J, Vishwasrao P, et al.
Front Oncol . 2022 Sep; 12:969429. PMID: 36147914
Sickle cell disease (SCD) is a serious global health problem, and currently, the only curative option is hematopoietic stem cell transplant (HCT). However, myeloablative total body irradiation (TBI)-based HCT is...
5.
Feasibility of a Novel Sparse Orthogonal Collimator-Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality
Abdelhamid A, Jiang L, Zuro D, Liu A, Madabushi S, Ghimire H, et al.
Front Oncol . 2022 Aug; 12:941814. PMID: 35924145
Total marrow irradiation (TMI) has significantly improved radiation conditioning for hematopoietic cell transplantation in hematologic diseases by reducing conditioning-induced toxicities and improving survival outcomes in relapsed/refractory patients. Recently, preclinical three-dimensional...
6.
Longitudinal Preclinical Imaging Characterizes Extracellular Drug Accumulation After Radiation Therapy in the Healthy and Leukemic Bone Marrow Vascular Microenvironment
Brooks J, Zuro D, Song J, Madabushi S, Sanchez J, Guha C, et al.
Int J Radiat Oncol Biol Phys . 2021 Nov; 112(4):951-963. PMID: 34767936
Purpose: Recent initial findings suggest that radiation therapy improves blood perfusion and cellular chemotherapy uptake in mice with leukemia. However, the ability of radiation therapy to influence drug accumulation in...
7.
First Multimodal, Three-Dimensional, Image-Guided Total Marrow Irradiation Model for Preclinical Bone Marrow Transplantation Studies
Zuro D, Madabushi S, Brooks J, Chen B, Goud J, Salhotra A, et al.
Int J Radiat Oncol Biol Phys . 2021 Jun; 111(3):671-683. PMID: 34119592
Purpose: Total marrow irradiation (TMI) has significantly advanced radiation conditioning for hematopoietic cell transplantation in hematologic malignancies by reducing conditioning-induced toxicities and improving survival outcomes in relapsed/refractory patients. However, the...
8.
Exosomes-driven lipolysis and bone marrow niche remodeling supports leukemia expansion
Kumar B, Orellana M, Brooks J, Madabushi S, Vishwasrao P, Parra L, et al.
Haematologica . 2020 Oct; 106(5):1484-1488. PMID: 33054109
No abstract available.
9.
Biophysical Characterization of the Leukemic Bone Marrow Vasculature Reveals Benefits of Neoadjuvant Low-Dose Radiation Therapy
Brooks J, Kumar B, Zuro D, Raybuck J, Madabushi S, Vishwasrao P, et al.
Int J Radiat Oncol Biol Phys . 2020 Aug; 109(1):60-72. PMID: 32841681
Purpose: Although vascular alterations in solid tumor malignancies are known to decrease therapeutic delivery, the effects of leukemia-induced bone marrow vasculature (BMV) alterations on therapeutic delivery are not well known....
10.
Automated in vivo Assessment of Vascular Response to Radiation using a Hybrid Theranostic X-ray Irradiator/Fluorescence Molecular Imaging System
Nouizi F, Brooks J, Zuro D, Madabushi S, Moreira D, Kortylewski M, et al.
IEEE Access . 2020 Jun; 8:93663-93670. PMID: 32542176
Hypofractionated stereotactic body radiotherapy treatments (SBRT) have demonstrated impressive results for the treatment of a variety of solid tumors. The role of tumor supporting vasculature damage in treatment outcome for...