Hemendra Ghimire
Overview
Explore the profile of Hemendra Ghimire including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
87
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0
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Recent Articles
1.
Ghimire H, Malekzadeh M, Lim J, Madabushi S, Zampini M, Camacho A, et al.
bioRxiv
. 2025 Jan;
PMID: 39803423
Background/objectives: Bone marrow (BM) adipocytes are critical in progressing solid tumor metastases and hematological malignancies across pediatric to aging populations. Single-point biopsies remain the gold standard for monitoring BM diseases,...
2.
Aniogo E, Kujawski M, Awuah D, Cha S, Espinosa R, Hui S, et al.
Front Immunol
. 2025 Jan;
15:1499471.
PMID: 39759518
Introduction: Although CAR-T cell therapy has limited efficacy against solid tumors, it has been hypothesized that prior treatment with Image-Guided Radiation Therapy (IGRT) would increase CAR-T cell tumor infiltration, leading...
3.
Ghimire H, Madabushi S, Vercellino J, Brooks J, Zuro D, Lim J, et al.
Front Oncol
. 2024 Oct;
14:1414488.
PMID: 39450249
Background: There is a need for therapies that can mitigate bone marrow dysfunction and organ toxicity that occur following myeloablative injury and reduced intensity conditioning regimens used in patients undergoing...
4.
Williams L, Li L, Yazaki P, Wong P, Hong T, Poku E, et al.
Cancer Med
. 2024 Feb;
13(3):e6909.
PMID: 38317590
Background: The potent immune effects of interleukin-2 (IL-2) for cancer therapy can be increased by genetic fusion of IL-2 to the Fc domain of an antibody (IL-2-Fc) or tumor targeted...
5.
Lim J, Madabushi S, Vishwasrao P, Song J, Abdelhamid A, Ghimire H, et al.
Front Oncol
. 2022 Nov;
12:1045016.
PMID: 36439420
Total body irradiation (TBI) is a commonly used conditioning regimen for hematopoietic stem cell transplant (HCT), but dose heterogeneity and long-term organ toxicity pose significant challenges. Total marrow irradiation (TMI),...
6.
Madabushi S, Fouda R, Ghimire H, Abdelhamid A, Lim J, Vishwasrao P, et al.
Front Oncol
. 2022 Sep;
12:969429.
PMID: 36147914
Sickle cell disease (SCD) is a serious global health problem, and currently, the only curative option is hematopoietic stem cell transplant (HCT). However, myeloablative total body irradiation (TBI)-based HCT is...
7.
Abdelhamid A, Jiang L, Zuro D, Liu A, Madabushi S, Ghimire H, et al.
Front Oncol
. 2022 Aug;
12:941814.
PMID: 35924145
Total marrow irradiation (TMI) has significantly improved radiation conditioning for hematopoietic cell transplantation in hematologic diseases by reducing conditioning-induced toxicities and improving survival outcomes in relapsed/refractory patients. Recently, preclinical three-dimensional...
8.
Ghimire H, Viennois E, Hu X, Qin G, Merlin D, Perera A
J Biophotonics
. 2022 Feb;
15(6):e202100307.
PMID: 35133076
This study uses infrared spectrometry coupled with data analysis techniques to understand colitis-induced alterations in the molecular components of serum samples. Using samples from 18 ulcerative colitis patients and 28...
9.
Ghimire H, Hu X, Qin G, Perera A
Biomed Opt Express
. 2020 Sep;
11(8):4679-4694.
PMID: 32923071
This study presents an application of infrared spectroscopy of sera for monitoring the efficacy of anti-TNFα therapy for inflammatory bowel diseases. Understanding the therapeutic response includes the analysis of absorption...
10.
Ghimire H, Garlapati C, Janssen E, Krishnamurti U, Qin G, Aneja R, et al.
Cancers (Basel)
. 2020 Jul;
12(7).
PMID: 32605072
Protein structural alterations, including misfolding and aggregation, are a hallmark of several diseases, including cancer. However, the possible clinical application of protein conformational analysis using infrared spectroscopy to detect cancer-associated...