Spyros Artavanis-Tsakonas
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Explore the profile of Spyros Artavanis-Tsakonas including associated specialties, affiliations and a list of published articles.
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5748
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Recent Articles
1.
Bhat G, Li K, Locke G, Theodorou M, Kilambi K, Hori K, et al.
Dev Cell
. 2024 Jun;
59(18):2506-2517.e6.
PMID: 38944040
We describe a next-generation Drosophila protein interaction map-"DPIM2"-established from affinity purification-mass spectrometry of 5,805 baits, covering the largest fraction of the Drosophila proteome. The network contains 32,668 interactions among 3,644...
2.
Ho D, Shaban M, Mahmood F, Ganguly P, Todeschini L, Van Vactor D, et al.
Proc Natl Acad Sci U S A
. 2024 Jun;
121(24):e2400732121.
PMID: 38838021
Cytoplasmic mislocalization and aggregation of TDP-43 protein are hallmarks of amyotrophic lateral sclerosis (ALS) and are observed in the vast majority of both familial and sporadic cases. How these two...
3.
Kankel M, Sen A, Lu L, Theodorou M, Dimlich D, McCampbell A, et al.
Genetics
. 2020 Apr;
215(3):747-766.
PMID: 32345615
Amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig's disease, is a devastating neurodegenerative disorder lacking effective treatments. ALS pathology is linked to mutations in >20 different genes indicating a...
4.
Sarraf S, Sideris D, Giagtzoglou N, Ni L, Kankel M, Sen A, et al.
Cell Rep
. 2019 Oct;
29(1):225-235.e5.
PMID: 31577952
PINK1 and Parkin are established mediators of mitophagy, the selective removal of damaged mitochondria by autophagy. PINK1 and Parkin have been proposed to act as tumor suppressors, as loss-of-function mutations...
5.
Ho D, Artavanis-Tsakonas S, Louvi A
Wiley Interdiscip Rev Dev Biol
. 2019 Sep;
9(1):e358.
PMID: 31502763
The role of the Notch signaling pathway in neural development has been well established over many years. More recent studies, however, have demonstrated that Notch continues to be expressed and...
6.
Ho D, Guruharsha K, Artavanis-Tsakonas S
Adv Exp Med Biol
. 2018 Jul;
1066:125-140.
PMID: 30030825
The Notch pathway controls a very broad spectrum of cell fates in metazoans during development, influencing proliferation, differentiation and cell death. Given its central role in normal development and homeostasis,...
7.
Engler A, Rolando C, Giachino C, Saotome I, Erni A, Brien C, et al.
Cell Rep
. 2018 Feb;
22(4):992-1002.
PMID: 29386140
Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of the adult forebrain from quiescent neural stem cells (NSCs). V-SVZ NSCs are a reservoir for new olfactory bulb (OB) neurons that migrate...
8.
Huttlin E, Bruckner R, Paulo J, Cannon J, Ting L, Baltier K, et al.
Nature
. 2017 May;
545(7655):505-509.
PMID: 28514442
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks...
9.
Ho D, Artavanis-Tsakonas S
Curr Top Dev Biol
. 2016 Mar;
116:17-33.
PMID: 26970611
The essential and highly conserved Notch signaling pathway controls a wide range of cell fate decisions during development, including cellular proliferation. Notch mediates both pro- and anti-proliferative effects in development,...
10.
Stoiber M, Olson S, May G, Duff M, Manent J, Obar R, et al.
Genome Res
. 2015 Aug;
25(11):1692-702.
PMID: 26294687
In eukaryotic cells, RNAs exist as ribonucleoprotein particles (RNPs). Despite the importance of these complexes in many biological processes, including splicing, polyadenylation, stability, transportation, localization, and translation, their compositions are...