Julian Mintseris
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Explore the profile of Julian Mintseris including associated specialties, affiliations and a list of published articles.
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36
Citations
2960
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Recent Articles
1.
Nardone C, Gao J, Seo H, Mintseris J, Ort L, Yip M, et al.
bioRxiv
. 2025 Mar;
PMID: 40027645
The midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome complex, revealing how established proteasomal components are...
2.
Van Vranken J, Li J, Mintseris J, Wei T, Sniezek C, Gadzuk-Shea M, et al.
Elife
. 2024 Nov;
13.
PMID: 39526730
In response to an ever-increasing demand of new small molecules therapeutics, numerous chemical and genetic tools have been developed to interrogate compound mechanism of action. Owing to its ability to...
3.
Dong Y, Bonin J, Devant P, Liang Z, Sever A, Mintseris J, et al.
Immunity
. 2024 May;
57(7):1533-1548.e10.
PMID: 38733997
Several interleukin-1 (IL-1) family members, including IL-1β and IL-18, require processing by inflammasome-associated caspases to unleash their activities. Here, we unveil, by cryoelectron microscopy (cryo-EM), two major conformations of the...
4.
Van Vranken J, Li J, Mintseris J, Wei T, Sniezek C, Gadzuk-Shea M, et al.
bioRxiv
. 2024 Feb;
PMID: 38328090
In response to an ever-increasing demand of new small molecules therapeutics, numerous chemical and genetic tools have been developed to interrogate compound mechanism of action. Owing to its ability to...
5.
Devant P, Dong Y, Mintseris J, Ma W, Gygi S, Wu H, et al.
Nature
. 2024 Jan;
625(7995):E17.
PMID: 38172642
No abstract available.
6.
Devant P, Dong Y, Mintseris J, Ma W, Gygi S, Wu H, et al.
Nature
. 2023 Nov;
624(7991):451-459.
PMID: 37993712
Inflammatory caspases are key enzymes in mammalian innate immunity that control the processing and release of interleukin-1 (IL-1)-family cytokines. Despite the biological importance, the structural basis for inflammatory caspase-mediated cytokine...
7.
Le V, Zhao B, Ramesh S, Toohey C, DeCosta A, Mintseris J, et al.
Proc Natl Acad Sci U S A
. 2023 Jun;
120(24):e2304874120.
PMID: 37279271
Activation of latent transforming growth factor (TGF)-β2 is incompletely understood. Unlike TGF-β1 and β3, the TGF-β2 prodomain lacks a seven-residue RGDLXX (L/I) integrin-recognition motif and is thought not to be...
8.
Erlandson S, Rawson S, Osei-Owusu J, Brock K, Liu X, Paulo J, et al.
Nat Chem Biol
. 2023 Apr;
19(8):1013-1021.
PMID: 37081311
The relaxin family peptide receptor 1 (RXFP1) is the receptor for relaxin-2, an important regulator of reproductive and cardiovascular physiology. RXFP1 is a multi-domain G protein-coupled receptor (GPCR) with an...
9.
Gassaway B, Li J, Rad R, Mintseris J, Mohler K, Levy T, et al.
Nat Methods
. 2022 Oct;
19(11):1371-1375.
PMID: 36280721
Mass-spectrometry-based phosphoproteomics has become indispensable for understanding cellular signaling in complex biological systems. Despite the central role of protein phosphorylation, the field still lacks inexpensive, regenerable, and diverse phosphopeptides with...
10.
Hollingsworth L, Sharif H, Griswold A, Fontana P, Mintseris J, Dagbay K, et al.
Nature
. 2021 Mar;
592(7856):778-783.
PMID: 33731932
Nucleotide-binding domain and leucine-rich repeat pyrin-domain containing protein 1 (NLRP1) is an inflammasome sensor that mediates the activation of caspase-1 to induce cytokine maturation and pyroptosis. Gain-of-function mutations of NLRP1...