Soundarapandian Vijayakumar
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Explore the profile of Soundarapandian Vijayakumar including associated specialties, affiliations and a list of published articles.
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13
Citations
241
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Recent Articles
1.
Beenken A, Shen T, Jin G, Ghotra A, Xu K, Nesanir K, et al.
Am J Physiol Renal Physiol
. 2024 Sep;
327(5):F775-F787.
PMID: 39265081
Proximal tubule endocytosis is essential to produce protein-free urine as well as to regulate system-wide metabolic pathways, such as the activation of Vitamin D. We have determined that the proximal...
2.
Schlieder I, Richard M, Nacar A, Rieger R, Bethge A, Vijayakumar S, et al.
Ann Vasc Surg
. 2019 May;
60:279-285.
PMID: 31103674
Background: With the advent of endovascular procedures, the indications for intervention in claudicants have become less strict. Many interventionalists, however, will not intervene in patients with lifestyle-limiting claudication unless they...
3.
Paragas N, Kulkarni R, Werth M, Schmidt-Ott K, Forster C, Deng R, et al.
J Clin Invest
. 2014 Jun;
124(7):2963-76.
PMID: 24937428
α-Intercalated cells (A-ICs) within the collecting duct of the kidney are critical for acid-base homeostasis. Here, we have shown that A-ICs also serve as both sentinels and effectors in the...
4.
Vijayakumar S, Dang S, Marinkovich M, Lazarova Z, Yoder B, Torres V, et al.
Am J Physiol Renal Physiol
. 2013 Dec;
306(6):F640-54.
PMID: 24370592
Basement membrane abnormalities have often been observed in kidney cysts of polycystic kidney disease (PKD) patients and animal models. There is an abnormal deposition of extracellular matrix molecules, including laminin-α3,β3,γ2...
5.
Vijayakumar S, Peng H, Schwartz G
Am J Physiol Renal Physiol
. 2013 May;
305(1):F90-9.
PMID: 23657851
A multidomain, multifunctional 230-kDa extracellular matrix (ECM) protein, hensin, regulates the adaptation of rabbit kidney to metabolic acidosis by remodeling collecting duct intercalated cells. Conditional deletion of hensin in intercalated...
6.
Peng H, Vijayakumar S, Schiene-Fischer C, Li H, Purkerson J, Malesevic M, et al.
J Biol Chem
. 2008 Dec;
284(10):6465-75.
PMID: 19112104
Hensin is a rabbit ortholog of DMBT1, a multifunctional, multidomain protein implicated in the regulation of epithelial differentiation, innate immunity, and tumorigenesis. Hensin in the extracellular matrix (ECM) induced morphological...
7.
Vijayakumar S, Erdjument-Bromage H, Tempst P, Al-Awqati Q
J Am Soc Nephrol
. 2008 Mar;
19(6):1079-91.
PMID: 18337486
Epithelial differentiation proceeds in at least two steps: Conversion of a nonepithelial cell into an epithelial sheet followed by terminal differentiation into the mature epithelial phenotype. It was recently discovered...
8.
Vijayakumar S, Takito J, Gao X, Schwartz G, Al-Awqati Q
J Cell Sci
. 2006 Nov;
119(Pt 23):4797-801.
PMID: 17130293
Epithelia, the most common variety of cells in complex organisms exist in many shapes. They are sheets of polarized cells that separate two compartments and selectively transport materials from one...
9.
Schwaderer A, Vijayakumar S, Al-Awqati Q, Schwartz G
Am J Physiol Renal Physiol
. 2005 Sep;
290(1):F148-58.
PMID: 16131647
The adaptation of the cortical collecting duct (CCD) to metabolic acidosis requires the polymerization and deposition in the extracellular matrix of the novel protein hensin. HCO3(-)-secreting beta-intercalated cells remove apical...
10.
Watanabe S, Tsuruoka S, Vijayakumar S, Fischer G, Zhang Y, Fujimura A, et al.
Am J Physiol Renal Physiol
. 2004 Sep;
288(1):F40-7.
PMID: 15353404
Cyclosporin A (CsA), a widely used immunosuppressant, causes distal renal tubular acidosis (dRTA). It exerts its immunosuppressive effect by a calcineurin-inhibitory complex with its cytosolic receptor, cyclophilin A. However, CsA...