Sophie E Acton
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Explore the profile of Sophie E Acton including associated specialties, affiliations and a list of published articles.
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29
Citations
2194
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Recent Articles
1.
Chin M, Reid B, Lachina V, Acton S, Coppens M
Biotechnol J
. 2023 Nov;
19(1):e2300359.
PMID: 37986209
Physical networks are ubiquitous in nature, but many of them possess a complex organizational structure that is difficult to recapitulate in artificial systems. This is especially the case in biomedical...
2.
Lim S, Joseph M, de Winde C, Acton S, Simoncelli S
Open Biol
. 2023 May;
13(5):220377.
PMID: 37161290
Upon initial immune challenge, dendritic cells (DCs) migrate to lymph nodes and interact with fibroblastic reticular cells (FRCs) via C-type lectin-like receptor 2 (CLEC-2). CLEC-2 binds to the membrane glycoprotein...
3.
Zhao J, Jung S, Li X, Li L, Kasinath V, Zhang H, et al.
J Clin Invest
. 2022 Dec;
132(24).
PMID: 36519543
The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Here, we investigated how fibroblastic reticular cells (FRCs) facilitate the tolerance induced by anti-CD40L in...
4.
Horsnell H, Tetley R, De Belly H, Makris S, Millward L, Benjamin A, et al.
Nat Immunol
. 2022 Jul;
23(8):1169-1182.
PMID: 35882934
Emergent physical properties of tissues are not readily understood by reductionist studies of their constituent cells. Here, we show molecular signals controlling cellular, physical, and structural properties and collectively determine...
5.
Gupta Y, Khanom A, Acton S
Front Immunol
. 2022 Mar;
13:733800.
PMID: 35355992
The tumour microenvironment (TME) presents a major block to anti-tumour immune responses and to effective cancer immunotherapy. The inflammatory mediators such as cytokines, chemokines, growth factors and prostaglandins generated in...
6.
Makris S, de Winde C, Horsnell H, Cantoral-Rebordinos J, Finlay R, Acton S
Dis Model Mech
. 2022 Jan;
15(1).
PMID: 35072206
Lymphoid tissue returns to a steady state once each immune response is resolved, and although this occurs multiple times throughout life, its structural integrity and functionality remain unaffected. Stromal cells...
7.
Menzel L, Zschummel M, Crowley T, Franke V, Grau M, Ulbricht C, et al.
Cell Rep
. 2021 Oct;
37(4):109878.
PMID: 34706240
Blood endothelial cells display remarkable plasticity depending on the demands of a malignant microenvironment. While studies in solid tumors focus on their role in metabolic adaptations, formation of high endothelial...
8.
de Winde C, George S, Crosas-Molist E, Hari-Gupta Y, Arp A, Benjamin A, et al.
iScience
. 2021 Sep;
24(9):102976.
PMID: 34485858
Melanoma is an aggressive skin cancer developing from melanocytes, frequently resulting in metastatic disease. Melanoma cells utilize amoeboid migration as mode of local invasion. Amoeboid invasion is characterized by rounded...
9.
Acton S, Onder L, Novkovic M, Martinez V, Ludewig B
Trends Immunol
. 2021 Aug;
42(9):782-794.
PMID: 34362676
Fibroblastic reticular cells (FRCs) are a crucial part of the stromal cell infrastructure of secondary lymphoid organs (SLOs). Lymphoid organ fibroblasts form specialized niches for immune cell interactions and thereby...
10.
de Winde C, Makris S, Millward L, Cantoral-Rebordinos J, Benjamin A, Martinez V, et al.
J Cell Sci
. 2021 Jun;
134(14).
PMID: 34184727
In adaptive immunity, CLEC-2+ dendritic cells (DCs) contact fibroblastic reticular cells (FRCs) inhibiting podoplanin-dependent actomyosin contractility, permitting FRC spreading and lymph node expansion. The molecular mechanisms controlling lymph node remodelling...