Sofia Gkountela
Overview
Explore the profile of Sofia Gkountela including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
1594
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0
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Recent Articles
1.
Weisberg E, Chowdhury B, Meng C, Case A, Ni W, Garg S, et al.
Blood Cancer J
. 2022 Jul;
12(7):110.
PMID: 35853853
Bromodomain-containing protein 9 (BRD9), an essential component of the SWI/SNF chromatin remodeling complex termed ncBAF, has been established as a therapeutic target in a subset of sarcomas and leukemias. Here,...
2.
Scheidmann M, Castro-Giner F, Strittmatter K, Krol I, Paasinen-Sohns A, Scherrer R, et al.
Cancer Res
. 2021 Dec;
82(4):681-694.
PMID: 34916221
Significance: A loss-of-function CRISPR screen in human CTC-derived xenografts identifies genes critical for individual steps of the metastatic cascade, suggesting novel drivers and treatment opportunities for metastatic breast cancers.
3.
Szczerba B, Castro-Giner F, Vetter M, Krol I, Gkountela S, Landin J, et al.
Nature
. 2019 Feb;
566(7745):553-557.
PMID: 30728496
A better understanding of the features that define the interaction between cancer cells and immune cells is important for the development of new cancer therapies. However, focus is often given...
4.
Gkountela S, Castro-Giner F, Szczerba B, Vetter M, Landin J, Scherrer R, et al.
Cell
. 2019 Jan;
176(1-2):98-112.e14.
PMID: 30633912
The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain largely unknown. Here, we...
5.
Vetter M, Landin J, Szczerba B, Castro-Giner F, Gkountela S, Donato C, et al.
Breast Cancer Res
. 2018 Nov;
20(1):141.
PMID: 30458879
Background: The presence of circulating tumor cells (CTCs) in patients with breast cancer correlates to a bad prognosis. Yet, CTCs are detectable in only a minority of patients with progressive...
6.
Krol I, Castro-Giner F, Maurer M, Gkountela S, Szczerba B, Scherrer R, et al.
Br J Cancer
. 2018 Aug;
119(4):487-491.
PMID: 30065256
Human glioblastoma (GBM) is a highly aggressive, invasive and hypervascularised malignant brain cancer. Individual circulating tumour cells (CTCs) are sporadically found in GBM patients, yet it is unclear whether multicellular...
7.
Castro-Giner F, Gkountela S, Donato C, Alborelli I, Quagliata L, Ng C, et al.
Diagnostics (Basel)
. 2018 May;
8(2).
PMID: 29747380
The field of cancer diagnostics has recently been impacted by new and exciting developments in the area of liquid biopsy. A liquid biopsy is a minimally invasive alternative to surgical...
8.
Clark A, Gkountela S, Chen D, Liu W, Sosa E, Sukhwani M, et al.
Stem Cell Reports
. 2017 Jun;
9(1):329-341.
PMID: 28579394
Primordial germ cells (PGCs) are the earliest embryonic progenitors in the germline. Correct formation of PGCs is critical to reproductive health as an adult. Recent work has shown that primate...
9.
Gkountela S, Szczerba B, Donato C, Aceto N
ESMO Open
. 2016 Nov;
1(4):e000078.
PMID: 27843628
The development of a metastatic disease is recognised as the cause of death of over 90% of patients diagnosed with cancer. Understanding the biological features of metastasis has been hampered...
10.
Gkountela S, Aceto N
Biol Direct
. 2016 Jul;
11:33.
PMID: 27457474
Unlabelled: More than 90 % of cancer-related deaths are due to the development of a systemic metastatic disease. Clearly, much remains to be understood about the biological principles that govern...