Francesc Castro-Giner
Overview
Explore the profile of Francesc Castro-Giner including associated specialties, affiliations and a list of published articles.
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44
Citations
2941
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Recent Articles
1.
Kurzeder C, Nguyen-Strauli B, Krol I, Ring A, Castro-Giner F, Nuesch M, et al.
Nat Med
. 2025 Jan;
PMID: 39856336
The presence of circulating tumor cell (CTC) clusters is associated with disease progression and reduced survival in a variety of cancer types. In breast cancer, preclinical studies showed that inhibitors...
2.
Regev O, Kizner M, Roncato F, Dadiani M, Saini M, Castro-Giner F, et al.
Front Immunol
. 2022 Aug;
13:849701.
PMID: 35911772
Breast tumors and their derived circulating cancer cells express the leukocyte β integrin ligand Intercellular adhesion molecule 1 (ICAM-1). We found that elevated ICAM-1 expression in breast cancer cells results...
3.
Toll-Riera M, Olombrada M, Castro-Giner F, Wagner A
Sci Adv
. 2022 Jul;
8(28):eabk3511.
PMID: 35857489
Climate change is gradual, but it can also cause brief extreme heat waves that can exceed the upper thermal limit of any one organism. To study the evolutionary potential of...
4.
Diamantopoulou Z, Castro-Giner F, Schwab F, Foerster C, Saini M, Budinjas S, et al.
Nature
. 2022 Jun;
607(7917):156-162.
PMID: 35732738
The metastatic spread of cancer is achieved by the haematogenous dissemination of circulating tumour cells (CTCs). Generally, however, the temporal dynamics that dictate the generation of metastasis-competent CTCs are largely...
5.
Scheidmann M, Castro-Giner F, Strittmatter K, Krol I, Paasinen-Sohns A, Scherrer R, et al.
Cancer Res
. 2021 Dec;
82(4):681-694.
PMID: 34916221
Significance: A loss-of-function CRISPR screen in human CTC-derived xenografts identifies genes critical for individual steps of the metastatic cascade, suggesting novel drivers and treatment opportunities for metastatic breast cancers.
6.
Krol I, Schwab F, Carbone R, Ritter M, Picocci S, De Marni M, et al.
Br J Cancer
. 2021 Mar;
125(1):23-27.
PMID: 33762721
Circulating tumour cell (CTC) clusters have been proposed to be major players in the metastatic spread of breast cancer, particularly during advanced disease stages. Yet, it is unclear whether or...
7.
Donato C, Kunz L, Castro-Giner F, Paasinen-Sohns A, Strittmatter K, Szczerba B, et al.
Cell Rep
. 2020 Sep;
32(10):108105.
PMID: 32905777
Circulating tumor cells (CTCs) are shed from solid cancers in the form of single or clustered cells, and the latter display an extraordinary ability to initiate metastasis. Yet, the biological...
8.
Watkins T, Lim E, Petkovic M, Elizalde S, Birkbak N, Wilson G, et al.
Nature
. 2020 Sep;
587(7832):126-132.
PMID: 32879494
Chromosomal instability in cancer consists of dynamic changes to the number and structure of chromosomes. The resulting diversity in somatic copy number alterations (SCNAs) may provide the variation necessary for...
9.
Diamantopoulou Z, Castro-Giner F, Aceto N
J Exp Med
. 2020 Jul;
217(8).
PMID: 32644115
Circulating tumor cells are tumor-derived pioneers responsible for the metastatic spread of cancer. Here, we outline recent discoveries, challenges, and future trends for circulating tumor cell investigations, arguing that the...
10.
Veen W, Globinska A, Jansen K, Straumann A, Kubo T, Verschoor D, et al.
Sci Adv
. 2020 May;
6(20):eaaz3559.
PMID: 32426497
B cells contribute to immune responses through the production of immunoglobulins, antigen presentation, and cytokine production. Several B cell subsets with distinct functions and polarized cytokine profiles have been reported....