Smitha R James
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Explore the profile of Smitha R James including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
1512
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Recent Articles
11.
Starlard-Davenport A, Tryndyak V, James S, Karpf A, Latendresse J, Beland F, et al.
Carcinogenesis
. 2009 Dec;
31(3):376-81.
PMID: 20008439
Breast cancer, the most common malignancy in women, emerges through a multistep process, encompassing the progressive sequential evolution of morphologically distinct stages from a normal cell to hyperplasia (with and...
12.
Rai K, Jafri I, Chidester S, James S, Karpf A, Cairns B, et al.
J Biol Chem
. 2009 Dec;
285(6):4110-4121.
PMID: 19946145
Although DNA methylation is critical for proper embryonic and tissue-specific development, how different DNA methyltransferases affect tissue-specific development and their targets remains unknown. We address this issue in zebrafish through...
13.
Choi J, James S, Link P, McCann S, Hong C, Davis W, et al.
Carcinogenesis
. 2009 Jul;
30(11):1889-97.
PMID: 19584139
Background: Global DNA hypomethylation may result in chromosomal instability and oncogene activation, and as a surrogate of systemic methylation activity, may be associated with breast cancer risk. Methods: Samples and...
14.
Link P, Gangisetty O, James S, Woloszynska-Read A, Tachibana M, Shinkai Y, et al.
Mol Cancer Res
. 2009 Jun;
7(6):851-62.
PMID: 19531572
The H3K9me2 histone methyltransferases G9a and GLP repress Mage-a class cancer germ-line (CG) antigen gene expression in murine embryonic stem (ES) cells, but the role of these enzymes in CG...
15.
Karpf A, Bai S, James S, Mohler J, Wilson E
Mol Cancer Res
. 2009 Apr;
7(4):523-35.
PMID: 19372581
Melanoma antigen gene protein-A11 (MAGE-11) of the MAGE family of cancer germ-line antigens increases androgen receptor (AR) transcriptional activity through its interaction with the AR NH(2)-terminal FXXLF motif. The present...
16.
Rai K, Huggins I, James S, Karpf A, Jones D, Cairns B
Cell
. 2008 Dec;
135(7):1201-12.
PMID: 19109892
Evidence for active DNA demethylation in vertebrates is accumulating, but the mechanisms and enzymes remain unclear. Using zebrafish embryos we provide evidence for 5-methylcytosine (5-meC) removal in vivo via the...
17.
Link P, Baer M, James S, Jones D, Karpf A
Cancer Res
. 2008 Nov;
68(22):9358-66.
PMID: 19010910
While the therapeutic activity of the deoxycytidine analogue decitabine is thought to reflect its ability to reactivate methylation-silenced genes, this agent is also known to trigger p53-dependent DNA damage responses....
18.
Pogribny I, Karpf A, James S, Melnyk S, Han T, Tryndyak V
Brain Res
. 2008 Aug;
1237:25-34.
PMID: 18694733
The maintenance of the cellular epigenomic landscape, which depends on the status of the one-carbon metabolic pathway, is essential for normal central nervous system development and function. In the present...
19.
Kinney S, Smiraglia D, James S, Moser M, Foster B, Karpf A
Mol Cancer Res
. 2008 Aug;
6(8):1365-74.
PMID: 18667590
We analyzed DNA methyltransferase (Dnmt) protein expression and DNA methylation patterns during four progressive stages of prostate cancer in the transgenic adenocarcinoma of mouse prostate (TRAMP) model, including prostatic intraepithelial...
20.
Bagnyukova T, Tryndyak V, Montgomery B, Churchwell M, Karpf A, James S, et al.
Carcinogenesis
. 2008 Jan;
29(3):638-46.
PMID: 18204080
Genotoxic carcinogens, including 2-acetylaminofluorene (2-AAF), in addition to exerting their genotoxic effects, often cause a variety of non-genotoxic alterations in cells. It is believed that these non-genotoxic effects may be...