Smitha R James
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Explore the profile of Smitha R James including associated specialties, affiliations and a list of published articles.
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26
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1512
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Recent Articles
1.
Sharma A, Albahrani M, Zhang W, Kufel C, James S, Odunsi K, et al.
Epigenetics
. 2019 Feb;
14(2):185-197.
PMID: 30764732
The POTE gene family consists of 14 homologous genes localized to autosomal pericentromeres, and a sub-set of POTEs are cancer-testis antigen (CTA) genes. POTEs are over-expressed in epithelial ovarian cancer...
2.
Barger C, Zhang W, Sharma A, Chee L, James S, Kufel C, et al.
Sci Rep
. 2018 Nov;
8(1):17136.
PMID: 30459449
The POTE family includes 14 genes in three phylogenetic groups. We determined POTE mRNA expression in normal tissues, epithelial ovarian and high-grade serous ovarian cancer (EOC, HGSC), and pan-cancer, and...
3.
Srivastava P, Paluch B, Matsuzaki J, James S, Collamat-Lai G, Blagitko-Dorfs N, et al.
Oncotarget
. 2016 Feb;
7(11):12840-56.
PMID: 26883197
Cancer testis antigens (CTAs) are promising cancer associated antigens in solid tumors, but in acute myeloid leukemia, dense promoter methylation silences their expression. Leukemia cell lines exposed to HMAs induce...
4.
Srivastava P, Paluch B, Matsuzaki J, James S, Collamat-Lai G, Taverna P, et al.
Epigenetics
. 2015 Mar;
10(3):237-46.
PMID: 25793777
We aimed to determine the effect of SGI-110 on methylation and expression of the cancer testis antigens (CTAs) NY-ESO-1 and MAGE-A in epithelial ovarian cancer (EOC) cells in vitro and...
5.
Griffiths E, Golding M, Srivastava P, Povinelli B, James S, Ford L, et al.
Haematologica
. 2014 Nov;
100(2):e49-52.
PMID: 25381132
No abstract available.
6.
Srivastava P, Paluch B, Matsuzaki J, James S, Collamat-Lai G, Karbach J, et al.
Leuk Res
. 2014 Sep;
38(11):1332-41.
PMID: 25260825
The mechanism of clinical action for the FDA approved hypomethylating drugs azacitidine and decitabine remains unresolved and in this context the potential immunomodulatory effect of these agents on leukemic cells...
7.
Odunsi K, Matsuzaki J, James S, Mhawech-Fauceglia P, Tsuji T, Miller A, et al.
Cancer Immunol Res
. 2014 Feb;
2(1):37-49.
PMID: 24535937
The cancer-testis/cancer-germline antigen NY-ESO-1 is a vaccine target in epithelial ovarian cancer (EOC), but its limited expression is a barrier to vaccine efficacy. As NY-ESO-1 is regulated by DNA methylation,...
8.
James S, Cedeno C, Sharma A, Zhang W, Mohler J, Odunsi K, et al.
Epigenetics
. 2013 Jul;
8(8):849-63.
PMID: 23839233
MAGEA11 is a cancer germline (CG) antigen and androgen receptor co-activator. Its expression in cancers other than prostate, and its mechanism of activation, has not been reported. In silico analyses...
9.
Liu L, van Groen T, Kadish I, Li Y, Wang D, James S, et al.
Clin Epigenetics
. 2012 Jun;
2(2):349-60.
PMID: 22704347
DNA methylation plays an integral role in development and aging through epigenetic regulation of genome function. DNA methyltransferase 1 (Dnmt1) is the most prevalent DNA methyltransferase that maintains genomic methylation...
10.
Woloszynska-Read A, James S, Song C, Jin B, Odunsi K, Karpf A
Cancer Immun
. 2010 Jul;
10:6.
PMID: 20649179
Expression of the cancer-germline (CG) (or cancer-testis) antigen gene BORIS/CTCFL has been proposed to mediate activation of CG antigen genes in cancer. Consistent with this idea, we have observed that...