Slavica Tudzarova
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Explore the profile of Slavica Tudzarova including associated specialties, affiliations and a list of published articles.
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19
Citations
411
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Recent Articles
1.
Raval K, Jamshidi N, Seyran B, Salwinski L, Pillai R, Yang L, et al.
Life Sci Alliance
. 2024 Sep;
7(12).
PMID: 39313296
Long-lived PFKFB3-expressing β-cells are dysfunctional partly because of prevailing glycolysis that compromises metabolic coupling of insulin secretion. Their accumulation in type 2 diabetes (T2D) appears to be related to the...
2.
Maglov J, Feng M, Lin D, Barkhouse K, Alexander A, Grbic M, et al.
Sci Rep
. 2023 Nov;
13(1):19343.
PMID: 37935795
Energy metabolism is a highly conserved process that balances generation of cellular energy and maintenance of redox homeostasis. It consists of five interconnected pathways: glycolysis, tricarboxylic acid cycle, pentose phosphate,...
3.
Min J, Ma F, Seyran B, Pellegrini M, Greeff O, Moncada S, et al.
Commun Biol
. 2022 Mar;
5(1):248.
PMID: 35318430
HIF1α and PFKFB3 play a critical role in the survival of damaged β-cells in type-2 diabetes while rendering β-cells non-responsive to glucose stimulation. To discriminate the role of PFKFB3 from...
4.
Min J, Zeng T, Roux M, Lazar D, Chen L, Tudzarova S
J Clin Endocrinol Metab
. 2021 May;
106(9):2505-2519.
PMID: 34019671
Diabetic retinopathy (DR) is the leading cause of blindness for adults in developed countries. Both microvasculopathy and neurodegeneration are implicated in mechanisms of DR development, with neuronal impairment preceding microvascular...
5.
Nomoto H, Pei L, Montemurro C, Rosenberger M, Furterer A, Coppola G, et al.
Diabetologia
. 2019 Nov;
63(1):149-161.
PMID: 31720731
Aims/hypothesis: The conserved hypoxia inducible factor 1 α (HIF1α) injury-response pro-survival pathway has recently been implicated in early beta cell dysfunction but slow beta cell loss in type 2 diabetes....
6.
Montemurro C, Nomoto H, Pei L, Parekh V, Vongbunyong K, Vadrevu S, et al.
Nat Commun
. 2019 Aug;
10(1):3507.
PMID: 31366929
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
7.
Montemurro C, Nomoto H, Pei L, Parekh V, Vongbunyong K, Vadrevu S, et al.
Nat Commun
. 2019 Jun;
10(1):2679.
PMID: 31213603
The islet in type 2 diabetes (T2D) is characterized by amyloid deposits derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by β-cells. In common with amyloidogenic proteins...
8.
Montemurro C, Vadrevu S, Gurlo T, Butler A, Vongbunyong K, Petcherski A, et al.
Cell Cycle
. 2017 Aug;
16(21):2086-2099.
PMID: 28820316
Cell replication is a fundamental attribute of growth and repair in multicellular organisms. Pancreatic beta-cells in adults rarely enter cell cycle, hindering the capacity for regeneration in diabetes. Efforts to...
9.
Tudzarova S, Mulholland P, Dey A, Stoeber K, Okorokov A, Williams G
Cell Cycle
. 2016 Sep;
15(21):2958-2972.
PMID: 27611229
DNA replication initiation is a key event in the cell cycle, which is dependent on 2 kinases - CDK2 and CDC7. Here we report a novel mechanism in which p53...
10.
Huggett M, Tudzarova S, Proctor I, Loddo M, Keane M, Stoeber K, et al.
Oncotarget
. 2016 Feb;
7(14):18495-507.
PMID: 26921250
Purpose: Cdc7 is a serine/threonine kinase which is responsible for the 'firing' of replication origins leading to initiation of DNA replication. Inhibition or depletion of Cdc7 in normal cells triggers...