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Simone Hornemann

Explore the profile of Simone Hornemann including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 57
Citations 2014
Followers 0
Related Specialties
Science
Microbiology
Molecular Biology
Top 10 Co-Authors
Adriano Aguzzi
Kurt Wuthrich
Petra Schwarz
K Peter R Nilsson
Daniel Heinzer
Merve Avar
Karl Frontzek
Magdalini Polymenidou
Barbara Christen
Assunta Senatore
Published In
PLoS Pathog
PLoS One
Proc Natl Acad Sci U S A
J Biol Chem
J Mol Biol
Affiliations
Soon will be listed here.
Recent Articles
1.
Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes
Yin J, Frick L, Scheidmann M, Liu T, Trevisan C, Dhingra A, et al.
Nat Biomed Eng . 2024 Dec; 9(1):127-148. PMID: 39633028
Arrayed CRISPR libraries extend the scope of gene-perturbation screens to non-selectable cell phenotypes. However, library generation requires assembling thousands of vectors expressing single-guide RNAs (sgRNAs). Here, by leveraging massively parallel...
2.
The ASC inflammasome adapter governs SAA-derived protein aggregation in inflammatory amyloidosis
Losa M, Emmenegger M, De Rossi P, Schurch P, Serdiuk T, Pengo N, et al.
EMBO Mol Med . 2024 Jul; 16(9):2024-2042. PMID: 39080493
Extracellularly released molecular inflammasome assemblies -ASC specks- cross-seed Aβ amyloid in Alzheimer's disease. Here we show that ASC governs the extent of inflammation-induced amyloid A (AA) amyloidosis, a systemic disease...
3.
Advancing surgical instrument safety: A screen of oxidative and alkaline prion decontaminants using real-time quaking-induced conversion with prion-coated steel beads as surgical instrument mimetic
Heinzer D, Avar M, Pfammatter M, Moos R, Schwarz P, Buhmann M, et al.
PLoS One . 2024 Jun; 19(6):e0304603. PMID: 38870196
Iatrogenic transmission of prions, the infectious agents of fatal Creutzfeldt-Jakob disease, through inefficiently decontaminated medical instruments remains a critical issue. Harsh chemical treatments are effective, but not suited for routine...
4.
Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region
Emmenegger M, De Cecco E, Lamparter D, Jacquat R, Riou J, Menges D, et al.
iScience . 2023 Jan; 26(2):105928. PMID: 36619367
Effective public health measures against SARS-CoV-2 require granular knowledge of population-level immune responses. We developed a Tripartite Automated Blood Immunoassay (TRABI) to assess the IgG response against three SARS-CoV-2 proteins....
5.
An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation
Avar M, Heinzer D, Thackray A, Liu Y, Hruska-Plochan M, Sellitto S, et al.
EMBO J . 2022 Oct; 41(23):e112338. PMID: 36254605
A defining characteristic of mammalian prions is their capacity for self-sustained propagation. Theoretical considerations and experimental evidence suggest that prion propagation is modulated by cell-autonomous and non-autonomous modifiers. Using a...
6.
A conformational switch controlling the toxicity of the prion protein
Frontzek K, Bardelli M, Senatore A, Henzi A, Reimann R, Bedir S, et al.
Nat Struct Mol Biol . 2022 Aug; 29(8):831-840. PMID: 35948768
Prion infections cause conformational changes of the cellular prion protein (PrP) and lead to progressive neurological impairment. Here we show that toxic, prion-mimetic ligands induce an intramolecular R208-H140 hydrogen bond...
7.
Concordance of cerebrospinal fluid real-time quaking-induced conversion across the European Creutzfeldt-Jakob Disease Surveillance Network
McKenzie N, Piconi G, Culeux A, Hammarin A, Stergiou C, Tzartos S, et al.
Eur J Neurol . 2022 May; 29(8):2431-2438. PMID: 35524506
Background And Purpose: Cerebrospinal fluid (CSF) real-time quaking-induced conversion (RT-QuIC) has a high degree of sensitivity and specificity for the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) and this has led...
8.
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies
Linsenmeier L, Mohammadi B, Shafiq M, Frontzek K, Bar J, Shrivastava A, et al.
Sci Adv . 2021 Nov; 7(48):eabj1826. PMID: 34818048
The prion protein (PrP) is a central player in neurodegenerative diseases, such as prion diseases or Alzheimer’s disease. In contrast to disease-promoting cell surface PrP, extracellular fragments act neuroprotective by...
9.
Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference
Heinzer D, Avar M, Pease D, Dhingra A, Yin J, Schaper E, et al.
PLoS Pathog . 2021 Oct; 17(10):e1010013. PMID: 34705895
The cellular prion protein PrPC is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of...
10.
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies
Emmenegger M, De Cecco E, Hruska-Plochan M, Eninger T, Schneider M, Barth M, et al.
EMBO Mol Med . 2021 Jul; 13(9):e14745. PMID: 34309222
While the initial pathology of Parkinson's disease and other α-synucleinopathies is often confined to circumscribed brain regions, it can spread and progressively affect adjacent and distant brain locales. This process...