Daniel Heinzer
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Explore the profile of Daniel Heinzer including associated specialties, affiliations and a list of published articles.
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13
Citations
139
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Recent Articles
1.
Heinzer D, Avar M, Pfammatter M, Moos R, Schwarz P, Buhmann M, et al.
PLoS One
. 2024 Jun;
19(6):e0304603.
PMID: 38870196
Iatrogenic transmission of prions, the infectious agents of fatal Creutzfeldt-Jakob disease, through inefficiently decontaminated medical instruments remains a critical issue. Harsh chemical treatments are effective, but not suited for routine...
2.
Harel I, Chen Y, Ziv I, Singh P, Heinzer D, Navarro Negredo P, et al.
Cell Rep
. 2024 May;
43(6):112787.
PMID: 38810650
Protein aggregation, which can sometimes spread in a prion-like manner, is a hallmark of neurodegenerative diseases. However, whether prion-like aggregates form during normal brain aging remains unknown. Here, we use...
3.
Avar M, Heinzer D, Thackray A, Liu Y, Hruska-Plochan M, Sellitto S, et al.
EMBO J
. 2022 Oct;
41(23):e112338.
PMID: 36254605
A defining characteristic of mammalian prions is their capacity for self-sustained propagation. Theoretical considerations and experimental evidence suggest that prion propagation is modulated by cell-autonomous and non-autonomous modifiers. Using a...
4.
Muller M, Avar M, Heinzer D, Emmenegger M, Aguzzi A, Pelkmans L, et al.
Sci Data
. 2021 Dec;
8(1):313.
PMID: 34857784
No abstract available.
5.
Heinzer D, Avar M, Pease D, Dhingra A, Yin J, Schaper E, et al.
PLoS Pathog
. 2021 Oct;
17(10):e1010013.
PMID: 34705895
The cellular prion protein PrPC is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of...
6.
Emmenegger M, De Cecco E, Hruska-Plochan M, Eninger T, Schneider M, Barth M, et al.
EMBO Mol Med
. 2021 Jul;
13(9):e14745.
PMID: 34309222
While the initial pathology of Parkinson's disease and other α-synucleinopathies is often confined to circumscribed brain regions, it can spread and progressively affect adjacent and distant brain locales. This process...
7.
Muller M, Avar M, Heinzer D, Emmenegger M, Aguzzi A, Pelkmans L, et al.
Sci Data
. 2021 Jun;
8(1):162.
PMID: 34183683
Coordination of RNA abundance and production rate with cell size has been observed in diverse organisms and cell populations. However, how cells achieve such 'scaling' of transcription with size is...
8.
Kara E, Crimi A, Wiedmer A, Emmenegger M, Manzoni C, Bandres-Ciga S, et al.
Cell Rep
. 2021 Jun;
35(10):109189.
PMID: 34107263
Neuropathological and experimental evidence suggests that the cell-to-cell transfer of α-synuclein has an important role in the pathogenesis of Parkinson's disease (PD). However, the mechanism underlying this phenomenon is not...
9.
Meisl G, Kurt T, Condado-Morales I, Bett C, Sorce S, Nuvolone M, et al.
Nat Struct Mol Biol
. 2021 Mar;
28(4):365-372.
PMID: 33767451
Prions consist of pathological aggregates of cellular prion protein and have the ability to replicate, causing neurodegenerative diseases, a phenomenon mirrored in many other diseases connected to protein aggregation, including...
10.
Inderbitzin A, Kok Y, Jorimann L, Kelley A, Neumann K, Heinzer D, et al.
PeerJ
. 2020 Dec;
8:e10321.
PMID: 33282555
Background: The persistence of the latent HIV-1 reservoir is a major obstacle to curing HIV-1 infection. HIV-1 integrates into the cellular genome and some targeted genomic loci are frequently detected...