Merve Avar
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Explore the profile of Merve Avar including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
140
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Recent Articles
1.
Heinzer D, Avar M, Pfammatter M, Moos R, Schwarz P, Buhmann M, et al.
PLoS One
. 2024 Jun;
19(6):e0304603.
PMID: 38870196
Iatrogenic transmission of prions, the infectious agents of fatal Creutzfeldt-Jakob disease, through inefficiently decontaminated medical instruments remains a critical issue. Harsh chemical treatments are effective, but not suited for routine...
2.
Avar M, Heinzer D, Thackray A, Liu Y, Hruska-Plochan M, Sellitto S, et al.
EMBO J
. 2022 Oct;
41(23):e112338.
PMID: 36254605
A defining characteristic of mammalian prions is their capacity for self-sustained propagation. Theoretical considerations and experimental evidence suggest that prion propagation is modulated by cell-autonomous and non-autonomous modifiers. Using a...
3.
Muller M, Avar M, Heinzer D, Emmenegger M, Aguzzi A, Pelkmans L, et al.
Sci Data
. 2021 Dec;
8(1):313.
PMID: 34857784
No abstract available.
4.
Heinzer D, Avar M, Pease D, Dhingra A, Yin J, Schaper E, et al.
PLoS Pathog
. 2021 Oct;
17(10):e1010013.
PMID: 34705895
The cellular prion protein PrPC is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of...
5.
Emmenegger M, De Cecco E, Hruska-Plochan M, Eninger T, Schneider M, Barth M, et al.
EMBO Mol Med
. 2021 Jul;
13(9):e14745.
PMID: 34309222
While the initial pathology of Parkinson's disease and other α-synucleinopathies is often confined to circumscribed brain regions, it can spread and progressively affect adjacent and distant brain locales. This process...
6.
Muller M, Avar M, Heinzer D, Emmenegger M, Aguzzi A, Pelkmans L, et al.
Sci Data
. 2021 Jun;
8(1):162.
PMID: 34183683
Coordination of RNA abundance and production rate with cell size has been observed in diverse organisms and cell populations. However, how cells achieve such 'scaling' of transcription with size is...
7.
Kara E, Crimi A, Wiedmer A, Emmenegger M, Manzoni C, Bandres-Ciga S, et al.
Cell Rep
. 2021 Jun;
35(10):109189.
PMID: 34107263
Neuropathological and experimental evidence suggests that the cell-to-cell transfer of α-synuclein has an important role in the pathogenesis of Parkinson's disease (PD). However, the mechanism underlying this phenomenon is not...
8.
Meisl G, Kurt T, Condado-Morales I, Bett C, Sorce S, Nuvolone M, et al.
Nat Struct Mol Biol
. 2021 Mar;
28(4):365-372.
PMID: 33767451
Prions consist of pathological aggregates of cellular prion protein and have the ability to replicate, causing neurodegenerative diseases, a phenomenon mirrored in many other diseases connected to protein aggregation, including...
9.
Avar M, Heinzer D, Steinke N, Dogancay B, Moos R, Lugan S, et al.
Life Sci Alliance
. 2020 Jul;
3(8).
PMID: 32606072
Transmission of prion infectivity to susceptible murine cell lines has simplified prion titration assays and has greatly reduced the need for animal experimentation. However, murine cell models suffer from technical...
10.
Sorce S, Nuvolone M, Russo G, Chincisan A, Heinzer D, Avar M, et al.
PLoS Pathog
. 2020 Jun;
16(6):e1008653.
PMID: 32598380
The clinical course of prion diseases is accurately predictable despite long latency periods, suggesting that prion pathogenesis is driven by precisely timed molecular events. We constructed a searchable genome-wide atlas...