Simone G J van Breda
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Explore the profile of Simone G J van Breda including associated specialties, affiliations and a list of published articles.
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23
Citations
246
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Recent Articles
1.
He Y, DeBenedictis J, Caiment F, van Breda S, de Kok T
Sci Rep
. 2024 Mar;
14(1):5096.
PMID: 38429310
No abstract available.
2.
He Y, DeBenedictis J, Caiment F, van Breda S, de Kok T
Sci Rep
. 2023 Oct;
13(1):18281.
PMID: 37880448
Diet is an important determinant of overall health, and has been linked to the risk of various cancers. To understand the mechanisms involved, transcriptomic responses from human intervention studies are...
3.
Berends J, van den Berg L, Guggeis M, Henckens N, Hossein I, de Joode M, et al.
Int J Mol Sci
. 2019 May;
20(9).
PMID: 31072023
Consumption of nitrate-rich beetroot juice (BRJ) by athletes induces a number of beneficial physiological health effects, which are linked to the formation of nitric oxide (NO) from nitrate. However, following...
4.
van Breda S, Briede J, de Kok T
Nutrients
. 2019 Jan;
11(1).
PMID: 30597948
Blueberries contain many different phytochemicals which might be responsible for their disease preventive properties. In a previously conducted human dietary intervention study, we showed that a 4-week intervention with blueberry⁻apple...
5.
Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes
Wolters J, van Breda S, Grossmann J, Fortes C, Caiment F, Kleinjans J
Toxicol Lett
. 2018 Mar;
289:1-13.
PMID: 29501571
We performed a multiple 'omics study by integrating data on epigenomic, transcriptomic, and proteomic perturbations associated with mitochondrial dysfunction in primary human hepatocytes caused by the liver toxicant valproic acid...
6.
van Breda S, Claessen S, van Herwijnen M, Theunissen D, Jennen D, de Kok T, et al.
Toxicology
. 2017 Nov;
393:160-170.
PMID: 29154799
Valproic acid (VPA) is a very potent anti-cancer and neuro-protective drug probably by its HDAC inhibiting properties, which may cause steatosis in the liver. The present study investigates the effect...
7.
van Breda S, de Kok T
Mol Nutr Food Res
. 2017 Nov;
62(1).
PMID: 29108107
There is ample scientific evidence suggesting that the health benefits of eating the right amounts of a variety of vegetables and fruit are the consequence of the combined action of...
8.
Wolters J, van Breda S, Caiment F, Claessen S, de Kok T, Kleinjans J
Chem Res Toxicol
. 2017 Aug;
30(10):1847-1854.
PMID: 28853863
Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs in the world. Despite its pharmacological importance, it may cause liver toxicity and steatosis through mitochondrial dysfunction. The...
9.
Wolters J, van Herwijnen M, Theunissen D, Jennen D, Van den Hof W, de Kok T, et al.
Chem Res Toxicol
. 2016 Dec;
29(12):2164-2174.
PMID: 27989131
Cyclosporine A (CsA) is an undecapeptide with strong immunosuppressant activities and is used a lot after organ transplantation. Furthermore, it may induce cholestasis in the liver. In general, the drug-induced...
10.
Rieswijk L, Brauers K, Coonen M, Jennen D, van Breda S, Kleinjans J
Mutagenesis
. 2016 Jun;
31(5):603-15.
PMID: 27338304
The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict the in vivo...