Jarno E J Wolters
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Explore the profile of Jarno E J Wolters including associated specialties, affiliations and a list of published articles.
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85
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Recent Articles
1.
van Mechelen R, Wolters J, Fredrich S, Bertens C, Gijbels M, Schenning A, et al.
Macromol Biosci
. 2023 May;
23(10):e2300075.
PMID: 37249127
Fibrosis of the filtering bleb is one of the main causes of failure after bleb-forming glaucoma surgery. Intraoperative application of mitomycin C (MMC) is the current gold standard to reduce...
2.
van Mechelen R, Wolters J, Herfs M, Bertens C, Gijbels M, Pinchuk L, et al.
Transl Vis Sci Technol
. 2022 Aug;
11(8):29.
PMID: 36018582
Purpose: The PreserFlo MicroShunt is an innovative implant for the surgical treatment of glaucoma. Although usually effective, surgeries can still fail due to fibrosis. This study was conducted to gain...
3.
Bertens C, van Mechelen R, Berendschot T, Gijs M, Wolters J, Gorgels T, et al.
Sci Rep
. 2021 Sep;
11(1):19217.
PMID: 34584185
The aim of this study was to evaluate repeatability, reproducibility, and agreement of three commonly used tonometers in animal research (TonoLab, TonoVet, and TonoPEN AVIA) in a cohort of 24...
4.
Wolters J, van Mechelen R, Al Majidi R, Pinchuk L, Webers C, Beckers H, et al.
Curr Opin Ophthalmol
. 2020 Dec;
32(2):148-159.
PMID: 33315724
Purpose Of Review: Mitomycin C (MMC) is an alkylating agent with extraordinary ability to crosslink DNA, preventing DNA synthesis. By this virtue, MMC is an important antitumor drug. In addition,...
5.
Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes
Wolters J, van Breda S, Grossmann J, Fortes C, Caiment F, Kleinjans J
Toxicol Lett
. 2018 Mar;
289:1-13.
PMID: 29501571
We performed a multiple 'omics study by integrating data on epigenomic, transcriptomic, and proteomic perturbations associated with mitochondrial dysfunction in primary human hepatocytes caused by the liver toxicant valproic acid...
6.
Briede J, Deferme L, Wolters J, Claessen S, van den Beucken T, Wagner R, et al.
Toxicol In Vitro
. 2018 Feb;
48:318-328.
PMID: 29432895
Regulation of DNA methylation plays a crucial role in biological processes and carcinogenesis. The formation of 5-hydroxymethylcytosine (5hmC) by oxidation of 5-methylcytosine (5mC) has been proposed as an intermediate of...
7.
Wolters J, van Breda S, Caiment F, Claessen S, de Kok T, Kleinjans J
Chem Res Toxicol
. 2017 Aug;
30(10):1847-1854.
PMID: 28853863
Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs in the world. Despite its pharmacological importance, it may cause liver toxicity and steatosis through mitochondrial dysfunction. The...
8.
Wolters J, van Herwijnen M, Theunissen D, Jennen D, Van den Hof W, de Kok T, et al.
Chem Res Toxicol
. 2016 Dec;
29(12):2164-2174.
PMID: 27989131
Cyclosporine A (CsA) is an undecapeptide with strong immunosuppressant activities and is used a lot after organ transplantation. Furthermore, it may induce cholestasis in the liver. In general, the drug-induced...
9.
Deferme L, Wolters J, Claessen S, Theunissen D, van den Beucken T, Wagner J, et al.
Chem Res Toxicol
. 2016 Aug;
29(9):1428-38.
PMID: 27509014
In recent years, it has been shown that free radicals not only react directly with DNA but also regulate epigenetic processes such as DNA methylation, which may be relevant within...
10.
Jiang J, Wolters J, Van Breda S, Kleinjans J, de Kok T
Expert Opin Drug Metab Toxicol
. 2015 Jul;
11(10):1523-37.
PMID: 26155718
Introduction: Due to its complex mechanisms and unpredictable occurrence, drug-induced liver injury (DILI) complicates drug identification and classification. Since species-specific differences in metabolism and pharmacokinetics exist, data obtained from animal...