Simone Daminelli
Overview
Explore the profile of Simone Daminelli including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
182
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0
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Recent Articles
1.
Salentin S, Adasme M, Heinrich J, Haupt V, Daminelli S, Zhang Y, et al.
Sci Rep
. 2017 Sep;
7(1):11401.
PMID: 28900272
Drug repositioning identifies new indications for known drugs. Here we report repositioning of the malaria drug amodiaquine as a potential anti-cancer agent. While most repositioning efforts emerge through serendipity, we...
2.
Duran C, Daminelli S, Thomas J, Haupt V, Schroeder M, Cannistraci C
Brief Bioinform
. 2017 Apr;
19(6):1183-1202.
PMID: 28453640
The bipartite network representation of the drug-target interactions (DTIs) in a biosystem enhances understanding of the drugs' multifaceted action modes, suggests therapeutic switching for approved drugs and unveils possible side...
3.
Stular T, Lesnik S, Rozman K, Schink J, Zdouc M, Ghysels A, et al.
J Med Chem
. 2016 Dec;
59(24):11069-11078.
PMID: 27936766
Drug discovery is usually focused on a single protein target; in this process, existing compounds that bind to related proteins are often ignored. We describe ProBiS plugin, extension of our...
4.
Haupt V, Aguilar Uvalle J, Salentin S, Daminelli S, Leonhardt F, Konc J, et al.
Curr Pharm Des
. 2016 Feb;
22(21):3124-34.
PMID: 26873186
Background: Drug repositioning aims to identify novel indications for existing drugs. One approach to repositioning exploits shared binding sites between the drug targets and other proteins. Here, we review the...
5.
Salentin S, Haupt V, Daminelli S, Schroeder M
Prog Biophys Mol Biol
. 2014 Jun;
116(2-3):174-86.
PMID: 24923864
Detection of remote binding site similarity in proteins plays an important role for drug repositioning and off-target effect prediction. Various non-covalent interactions such as hydrogen bonds and van-der-Waals forces drive...
6.
Haupt V, Daminelli S, Schroeder M
PLoS One
. 2013 Jun;
8(6):e65894.
PMID: 23805191
Drug repositioning applies established drugs to new disease indications with increasing success. A pre-requisite for drug repurposing is drug promiscuity (polypharmacology) - a drug's ability to bind to several targets....
7.
Daminelli S, Haupt V, Reimann M, Schroeder M
Integr Biol (Camb)
. 2012 Apr;
4(7):778-88.
PMID: 22538435
Recently, there has been much interest in gene-disease networks and polypharmacology as a basis for drug repositioning. Here, we integrate data from structural and chemical databases to create a drug-target-disease...
8.
de Palma A, Roveri A, Zaccarin M, Benazzi L, Daminelli S, Pantano G, et al.
J Chromatogr A
. 2010 Jul;
1217(33):5328-36.
PMID: 20621298
Since red blood cells (RBCs) lack nuclei and organelles, cell membrane is their main load-bearing component and, according to a dynamic interaction with the cytoskeleton compartment, plays a pivotal role...