Sebastian Salentin
Overview
Explore the profile of Sebastian Salentin including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
15
Citations
1319
Followers
0
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Related Specialties
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Recent Articles
1.
Bolz S, Salentin S, Jennings G, Haupt V, Sterneckert J, Schroeder M
Comput Struct Biotechnol J
. 2021 Jul;
19:3674-3681.
PMID: 34285770
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a frequent cause of autosomal dominant Parkinson's disease (PD) and have been associated with familial and sporadic PD. Reducing the kinase activity...
2.
Adasme M, Linnemann K, Bolz S, Kaiser F, Salentin S, Haupt V, et al.
Nucleic Acids Res
. 2021 May;
49(W1):W530-W534.
PMID: 33950214
With the growth of protein structure data, the analysis of molecular interactions between ligands and their target molecules is gaining importance. PLIP, the protein-ligand interaction profiler, detects and visualises these...
3.
Adasme M, Bolz S, Adelmann L, Salentin S, Haupt V, Moreno-Rodriguez A, et al.
Int J Mol Sci
. 2020 Nov;
21(22).
PMID: 33233837
Chagas disease, caused by the parasite , affects millions of people in South America. The current treatments are limited, have severe side effects, and are only partially effective. Drug repositioning,...
4.
Kaiser F, Krautwurst S, Salentin S, Haupt V, Leberecht C, Bittrich S, et al.
Sci Rep
. 2020 Jul;
10(1):12647.
PMID: 32724042
Storage and directed transfer of information is the key requirement for the development of life. Yet any information stored on our genes is useless without its correct interpretation. The genetic...
5.
Juarez-Saldivar A, Schroeder M, Salentin S, Haupt V, Saavedra E, Vazquez C, et al.
Int J Mol Sci
. 2020 Jun;
21(12).
PMID: 32560043
Chagas disease, caused by (), affects nearly eight million people worldwide. There are currently only limited treatment options, which cause several side effects and have drug resistance. Thus, there is...
6.
Adasme M, Parisi D, Van Belle K, Salentin S, Haupt V, Jennings G, et al.
PLoS One
. 2020 May;
15(5):e0233089.
PMID: 32459810
Many drugs are promiscuous and bind to multiple targets. On the one hand, these targets may be linked to unwanted side effects, but on the other, they may achieve a...
7.
Struble T, Alvarez J, Brown S, Chytil M, Cisar J, DesJarlais R, et al.
J Med Chem
. 2020 Apr;
63(16):8667-8682.
PMID: 32243158
Artificial intelligence and machine learning have demonstrated their potential role in predictive chemistry and synthetic planning of small molecules; there are at least a few reports of companies employing synthetic...
8.
Bonnardel F, Mariethoz J, Salentin S, Robin X, Schroeder M, Perez S, et al.
Nucleic Acids Res
. 2018 Sep;
47(D1):D1236-D1244.
PMID: 30239928
Lectins, and related receptors such as adhesins and toxins, are glycan-binding proteins from all origins that decipher the glycocode, i.e. the structural information encoded in the conformation of complex carbohydrates...
9.
Kaiser F, Bittrich S, Salentin S, Leberecht C, Haupt V, Krautwurst S, et al.
PLoS Comput Biol
. 2018 Apr;
14(4):e1006101.
PMID: 29659563
The origin of the machinery that realizes protein biosynthesis in all organisms is still unclear. One key component of this machinery are aminoacyl tRNA synthetases (aaRS), which ligate tRNAs to...
10.
Baldow C, Salentin S, Schroeder M, Roeder I, Glauche I
PLoS Comput Biol
. 2017 Dec;
13(12):e1005898.
PMID: 29244826
Over the past decades, quantitative methods linking theory and observation became increasingly important in many areas of life science. Subsequently, a large number of mathematical and computational models has been...