Janez Konc
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Explore the profile of Janez Konc including associated specialties, affiliations and a list of published articles.
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65
Citations
711
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Recent Articles
1.
Rozman K, Ghysels A, Janezic D, Konc J
Sci Rep
. 2024 Apr;
14(1):9118.
PMID: 38643335
We introduce a new algorithm MaxCliqueWeight for identifying a maximum weight clique in a weighted graph, and its variant MaxCliqueDynWeight with dynamically varying bounds. This algorithm uses an efficient branch-and-bound...
2.
Simon M, Mikec S, Atanur S, Konc J, Morton N, Horvat S, et al.
Genes Genomics
. 2024 Mar;
46(5):557-575.
PMID: 38483771
Background: Analysing genomes of animal model organisms is widely used for understanding the genetic basis of complex traits and diseases, such as obesity, for which only a few mouse models...
3.
Lisgarten D, Palmer R, Cooper J, Naylor C, Talbert R, Howlin B, et al.
BMC Chem
. 2023 Jul;
17(1):91.
PMID: 37501200
The crystal structure of orthorhombic Bovine Pancreatic Ribonuclease A has been determined to 0.85 Å resolution using low temperature, 100 K, synchrotron X-ray data collected at 16000 keV (λ = ...
4.
Konc J, Janezic D
Biophys Rev
. 2022 Dec;
14(6):1413-1421.
PMID: 36532870
Drug development is a lengthy and challenging process that can be accelerated at early stages by new mathematical approaches and modern computers. To address this important issue, we are developing...
5.
Pavlin A, Lovse A, Bajc G, Otonicar J, Kujovic A, Lengar Z, et al.
Commun Biol
. 2022 Nov;
5(1):1286.
PMID: 36434275
Bacillus thuringiensis serovar israelensis is the most widely used biopesticide against insects, including vectors of animal and human diseases. Among several extrachromosomal elements, this endospore-forming entomopathogen harbors two bacteriophages: a...
6.
Simon M, Mikec S, Morton N, Atanur S, Konc J, Horvat S, et al.
Mamm Genome
. 2022 Nov;
34(1):12-31.
PMID: 36414820
Alternative polyadenylation (APA) determines mRNA stability, localisation, translation and protein function. Several diseases, including obesity, have been linked to APA. Studies have shown that single nucleotide polymorphisms in polyadenylation signals...
7.
Konc J, Janezic D
J Chem Inf Model
. 2022 Oct;
62(22):5821-5829.
PMID: 36269348
ProBiS (Protein Binding Sites), a local structure-based comparison algorithm, is used in the new ProBiS-Fold web server to annotate human structures from the AlphaFold database without a corresponding structure in...
8.
Proj M, De Jonghe S, Loy T, Jukic M, Meden A, Ciber L, et al.
Front Pharmacol
. 2022 Apr;
13:855653.
PMID: 35370691
We present a state-of-the-art virtual screening workflow aiming at the identification of novel CC chemokine receptor 7 (CCR7) antagonists. Although CCR7 is associated with a variety of human diseases, such...
9.
Mikec S, Simon M, Morton N, Atanur S, Konc J, Dovc P, et al.
Mol Biol Rep
. 2022 Mar;
49(6):4619-4631.
PMID: 35347545
Background: Adipose tissue hypoxia and members of the hypoxia-inducible factor alpha (HIFA) are involved in development of obesity. However, the mechanism and functions of HIF3A, one of three HIFA paralogs,...
10.
Konc J, Lesnik S, Skrlj B, Sova M, Proj M, Knez D, et al.
J Chem Inf Model
. 2022 Mar;
62(6):1573-1584.
PMID: 35289616
The protein data bank (PDB) is a rich source of protein ligand structures, but ligands are not explicitly used in current docking algorithms. We have developed ProBiS-Dock, a docking algorithm...