Simona Cristea
Overview
Explore the profile of Simona Cristea including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
630
Followers
0
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Recent Articles
1.
Dilly J, Hoffman M, Abbassi L, Li Z, Paradiso F, Parent B, et al.
Cancer Discov
. 2024 Jul;
14(11):2135-2161.
PMID: 38975874
KRAS inhibitors demonstrate clinical efficacy in pancreatic ductal adenocarcinoma (PDAC); however, resistance is common. Among patients with KRASG12C-mutant PDAC treated with adagrasib or sotorasib, mutations in PIK3CA and KRAS, and...
2.
Janiszewska M, Tabassum D, Castano Z, Cristea S, Yamamoto K, Kingston N, et al.
Nat Cell Biol
. 2024 Mar;
26(5):841.
PMID: 38443568
No abstract available.
3.
Liu Y, Altreuter J, Bodapati S, Cristea S, Wong C, Wu C, et al.
Cell Genom
. 2024 Jan;
4(1):100444.
PMID: 38190106
Immune checkpoint blockade (ICB) therapy targeting cytotoxic T-lymphocyte-associated protein 4, programmed death 1, and programmed death ligand 1 has shown durable remission and clinical success across different cancer types. However,...
4.
Nishida J, Cristea S, Bodapati S, Puleo J, Bai G, Patel A, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(49):e2316763120.
PMID: 38011567
Immune escape is a prerequisite for tumor growth. We previously described a decline in intratumor activated cytotoxic T cells and T cell receptor (TCR) clonotype diversity in invasive breast carcinomas...
5.
Chen Z, Giotti B, Kaluzova M, Vallcorba M, Rawat K, Price G, et al.
J Clin Invest
. 2023 Sep;
133(22).
PMID: 37733448
Monocytes and monocyte-derived macrophages (MDMs) from blood circulation infiltrate glioblastoma (GBM) and promote growth. Here, we show that PDGFB-driven GBM cells induce the expression of the potent proinflammatory cytokine IL-1β...
6.
Hoetker M, Yagi M, Di Stefano B, Langerman J, Cristea S, Wong L, et al.
Nat Cell Biol
. 2023 Jul;
25(8):1121-1134.
PMID: 37460697
The epigenetic mechanisms that maintain differentiated cell states remain incompletely understood. Here we employed histone mutants to uncover a crucial role for H3K36 methylation in the maintenance of cell identities...
7.
Walentynowicz K, Engelhardt D, Cristea S, Yadav S, Onubogu U, Salatino R, et al.
Cell Rep
. 2023 Mar;
42(3):112235.
PMID: 36920905
Glioblastoma (GBM) is the most aggressive brain tumor, with a median survival of ∼15 months. Targeted approaches have not been successful in this tumor type due to the large extent...
8.
Aleckovic M, Cristea S, Gil Del Alcazar C, Yan P, Ding L, Krop E, et al.
Nat Commun
. 2022 Dec;
13(1):7558.
PMID: 36476730
Cancer prevention has a profound impact on cancer-associated mortality and morbidity. We previously identified TGFβ signaling as a candidate regulator of mammary epithelial cells associated with breast cancer risk. Here,...
9.
Boonen R, Wiegant W, Celosse N, Vroling B, Heijl S, Kote-Jarai Z, et al.
Cancer Res
. 2021 Dec;
82(4):615-631.
PMID: 34903604
Significance: Quantitative assessment of the functional consequences of CHEK2 variants of uncertain significance identifies damaging variants associated with increased cancer risk, which may aid in the clinical management of patients...
10.
Koh S, Dontchos B, Bossuyt V, Edmonds C, Cristea S, Melkonjan N, et al.
NPJ Precis Oncol
. 2021 Sep;
5(1):85.
PMID: 34548623
Systematic collection of fresh tissues for research at the time of diagnostic image-guided breast biopsy has the potential to fuel a wide variety of innovative studies. Here we report the...