Simon Messner
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Explore the profile of Simon Messner including associated specialties, affiliations and a list of published articles.
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20
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1755
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Recent Articles
1.
Carmody T, Park R, Bennett E, Kuret E, Klein B, Costa A, et al.
Neurol Ther
. 2024 Jun;
13(4):1219-1235.
PMID: 38865073
Introduction: Existing qualitative research on early-stage Parkinson's disease draws on patients' reported disease experience, aiming to capture the symptoms and impacts most relevant to patients living with the disease. As...
2.
Messner S, Fredriksson L, Lauschke V, Roessger K, Escher C, Bober M, et al.
Appl In Vitro Toxicol
. 2020 Sep;
4(1):1-12.
PMID: 32953943
Three-Dimensional (3D) liver microtissues, specifically prepared from primary human hepatocytes (PHH) in coculture with nonparenchymal cells (NPCs), have been shown to be a valuable tool for toxicology. However, a lack...
3.
Schoeler K, Aufschnaiter A, Messner S, Derudder E, Herzog S, Villunger A, et al.
FEBS J
. 2019 May;
286(18):3566-3581.
PMID: 31120187
Upon activation by antigen, B cells form germinal centres where they clonally expand and introduce affinity-enhancing mutations into their B-cell receptor genes. Somatic mutagenesis and class switch recombination (CSR) in...
4.
Woodhead J, Paech F, Maurer M, Engelhardt M, Schmitt-Hoffmann A, Spickermann J, et al.
Clin Transl Sci
. 2018 Jun;
11(5):498-505.
PMID: 29877622
Elevations of liver enzymes have been observed in clinical trials with BAL30072, a novel antibiotic. In vitro assays have identified potential mechanisms for the observed hepatotoxicity, including electron transport chain...
5.
Prestigiacomo V, Weston A, Messner S, Lampart F, Suter-Dick L
PLoS One
. 2017 Jul;
12(6):e0179995.
PMID: 28665955
Background & Aims: Currently most liver fibrosis research is performed in vivo, since suitable alternative in vitro systems which are able to recapitulate the cellular events leading to liver fibrosis...
6.
Proctor W, Foster A, Vogt J, Summers C, Middleton B, Pilling M, et al.
Arch Toxicol
. 2017 Jun;
91(8):2849-2863.
PMID: 28612260
Drug-induced liver injury (DILI) continues to be a major source of clinical attrition, precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need for more predictive tools to...
7.
Paech F, Messner S, Spickermann J, Wind M, Schmitt-Hoffmann A, Witschi A, et al.
Arch Toxicol
. 2017 May;
91(11):3647-3662.
PMID: 28536862
BAL30072 is a new monocyclic β-lactam antibiotic under development which provides a therapeutic option for the treatment of severe infections caused by multi-drug-resistant Gram-negative bacteria. Despite the absence of liver...
8.
Ghosh H, Auguadri L, Battaglia S, Simone Thirouin Z, Zemoura K, Messner S, et al.
Nat Commun
. 2016 Nov;
7:13365.
PMID: 27819299
GABA receptors (GABARs) mediate the majority of fast inhibitory neurotransmission in the brain via synergistic association with the postsynaptic scaffolding protein gephyrin and its interaction partners. However, unlike their counterparts...
9.
Hendriks D, Fredriksson Puigvert L, Messner S, Mortiz W, Ingelman-Sundberg M
Sci Rep
. 2016 Oct;
6:35434.
PMID: 27759057
Drug-induced cholestasis (DIC) is poorly understood and its preclinical prediction is mainly limited to assessing the compound's potential to inhibit the bile salt export pump (BSEP). Here, we evaluated two...
10.
Bruderer R, Bernhardt O, Gandhi T, Miladinovic S, Cheng L, Messner S, et al.
Mol Cell Proteomics
. 2015 Mar;
14(5):1400-10.
PMID: 25724911
The data-independent acquisition (DIA) approach has recently been introduced as a novel mass spectrometric method that promises to combine the high content aspect of shotgun proteomics with the reproducibility and...