Matthias Altmeyer
Overview
Explore the profile of Matthias Altmeyer including associated specialties, affiliations and a list of published articles.
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71
Citations
4350
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Recent Articles
1.
van de Kooij B, van der Wal F, Rother M, Wiegant W, Creixell P, Stout M, et al.
Nat Commun
. 2024 Aug;
15(1):7076.
PMID: 39152113
During the repair of interstrand crosslinks (ICLs) a DNA double-strand break (DSB) is generated. The Fanconi anemia (FA) core complex, which is recruited to ICLs, promotes high-fidelity repair of this...
2.
van de Kooij B, van der Wal F, Rother M, Creixell P, Stout M, Wiegant W, et al.
bioRxiv
. 2023 Sep;
PMID: 37732274
Homologous Recombination (HR) is a high-fidelity repair mechanism of DNA Double-Strand Breaks (DSBs), which are induced by irradiation, genotoxic chemicals or physiological DNA damaging processes. DSBs are also generated as...
3.
Spegg V, Altmeyer M
Chromosoma
. 2023 Aug;
133(1):15-36.
PMID: 37581649
Genome stability is key for healthy cells in healthy organisms, and deregulated maintenance of genome integrity is a hallmark of aging and of age-associated diseases including cancer and neurodegeneration. To...
4.
Schmolka N, Karemaker I, Cardoso da Silva R, Recchia D, Spegg V, Bhaskaran J, et al.
Nat Commun
. 2023 Jun;
14(1):3848.
PMID: 37385984
The Nucleosome Remodeling and Deacetylation (NuRD) complex is a crucial regulator of cellular differentiation. Two members of the Methyl-CpG-binding domain (MBD) protein family, MBD2 and MBD3, are known to be...
5.
Krishnan A, Spegg V, Dettwiler S, Schraml P, Moch H, Dedes K, et al.
Mod Pathol
. 2023 Mar;
36(7):100167.
PMID: 36990278
PARP inhibitors (PARPi) are increasingly used in breast cancer therapy, including high-grade triple-negative breast cancer (TNBC) treatment. Varying treatment responses and PARPi resistance with relapse currently pose limitations to the...
6.
Spegg V, Panagopoulos A, Stout M, Krishnan A, Reginato G, Imhof R, et al.
Nat Struct Mol Biol
. 2023 Mar;
30(4):451-462.
PMID: 36894693
RPA has been shown to protect single-stranded DNA (ssDNA) intermediates from instability and breakage. RPA binds ssDNA with sub-nanomolar affinity, yet dynamic turnover is required for downstream ssDNA transactions. How...
7.
Mosler T, Baymaz H, Graf J, Mikicic I, Blattner G, Bartlett E, et al.
Nucleic Acids Res
. 2022 Nov;
50(20):11600-11618.
PMID: 36350633
PARP1 mediates poly-ADP-ribosylation of proteins on chromatin in response to different types of DNA lesions. PARP inhibitors are used for the treatment of BRCA1/2-deficient breast, ovarian, and prostate cancer. Loss...
8.
Singh J, Noordermeer S, Jimenez-Sainz J, Maranon D, Altmeyer M
Front Genet
. 2022 Aug;
13:993889.
PMID: 36035119
No abstract available.
9.
Groelly F, Dagg R, Petropoulos M, Rossetti G, Prasad B, Panagopoulos A, et al.
Mol Cell
. 2022 Aug;
82(18):3382-3397.e7.
PMID: 36002001
Aberrant replication causes cells lacking BRCA2 to enter mitosis with under-replicated DNA, which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here, we identify genome-wide the sites where...
10.
Bolck H, Przetocka S, Meier R, von Aesch C, Zurfluh C, Hanggi K, et al.
Cells
. 2022 Feb;
11(4).
PMID: 35203293
Human CtIP is best known for its role in DNA end resection to initiate DNA double-strand break repair by homologous recombination. Recently, CtIP has also been shown to protect reversed...