Michael O Hottiger
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Explore the profile of Michael O Hottiger including associated specialties, affiliations and a list of published articles.
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152
Citations
8481
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Recent Articles
1.
Cereghetti A, Turko P, Cheng P, Benke S, Al Hrout A, Dzung A, et al.
JID Innov
. 2025 Jan;
5(2):100319.
PMID: 39867570
In cutaneous melanoma, epigenetic dysregulation is implicated in drug resistance and tumor immune escape. However, the epigenetic mechanisms that influence immune escape remain poorly understood. To elucidate how epigenetic dysregulation...
2.
Manetsch P, Hottiger M
Bioessays
. 2024 Nov;
47(2):e2400087.
PMID: 39502005
Cancer cells exploit mechanisms to evade immune detection triggered by aberrant self-nucleic acids (NA). PARP7, a key player in this immune evasion strategy, has emerged as a potential target for...
3.
Bohi F, Hottiger M
Biomedicines
. 2024 Jul;
12(7).
PMID: 39062190
The emergence of PARP inhibitors as a therapeutic strategy for tumors with high genomic instability, particularly those harboring BRCA mutations, has advanced cancer treatment. However, recent advances have illuminated a...
4.
Zhang Q, Xian W, Li Z, Lu Q, Chen X, Ge J, et al.
Cell Rep
. 2024 Feb;
43(2):113789.
PMID: 38368608
Under stress conditions, translationally stalled mRNA and associated proteins undergo liquid-liquid phase separation and condense into cytoplasmic foci called stress granules (SGs). Many viruses hijack SGs for their pathogenesis; however,...
5.
Rupasinghe M, Bersaglieri C, Leslie Pedrioli D, Pedrioli P, Panatta M, Hottiger M, et al.
EMBO Rep
. 2024 Feb;
25(3):1453-1468.
PMID: 38332149
Pluripotency is established in E4.5 preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of pluripotency, however, their gene expression signature only partially resembles that of developmental ground-state. Induced PRAMEL7...
6.
Schwarz S, Xu J, Gunasekera K, Schurmann D, Vagbo C, Ferrari E, et al.
Nat Commun
. 2024 Jan;
15(1):184.
PMID: 38167803
The intracellular ATP-ribosyltransferases PARP1 and PARP2, contribute to DNA base excision repair (BER) and DNA demethylation and have been implicated in epigenetic programming in early mammalian development. Recently, proteomic analyses...
7.
Manetsch P, Bohi F, Nowak K, Leslie Pedrioli D, Hottiger M
Proc Natl Acad Sci U S A
. 2023 Nov;
120(49):e2309047120.
PMID: 38011562
PARP7 was reported to promote tumor growth in a cell-autonomous manner and by repressing the antitumor immune response. Nevertheless, the molecular mechanism of how PARP7-mediated ADP-ribosylation exerts these effects in...
8.
Ferretti L, Bohi F, Leslie Pedrioli D, Cheng P, Ferrari E, Baumgaertner P, et al.
Cancer Res
. 2023 Sep;
83(23):3974-3988.
PMID: 37729428
Significance: PARP inhibitors can overcome resistance to MAPK inhibitors by activating autophagic cell death and reversing phenotype switching, suggesting that this synergistic combination could help improve the prognosis of patients...
9.
Kamaletdinova T, Zong W, Urbanek P, Wang S, Sannai M, Grigaravicius P, et al.
Cells
. 2023 Aug;
12(16).
PMID: 37626888
Poly(ADP-ribose) polymerase-1 (PARP1) binds DNA lesions to catalyse poly(ADP-ribosyl)ation (PARylation) using NAD+ as a substrate. PARP1 plays multiple roles in cellular activities, including DNA repair, transcription, cell death, and chromatin...
10.
Guldenpfennig A, Hopp A, Muskalla L, Manetsch P, Raith F, Hellweg L, et al.
Nucleic Acids Res
. 2023 Aug;
51(17):9248-9265.
PMID: 37587695
Though the effect of the recently identified mitochondrial NAD+ transporter SLC25A51 on glucose metabolism has been described, its contribution to other NAD+-dependent processes throughout the cell such as ADP-ribosylation remains...