Simon Linder
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Explore the profile of Simon Linder including associated specialties, affiliations and a list of published articles.
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20
Citations
284
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Recent Articles
1.
Azizi Z, Linder S, Ruiz M, Alipour P, Raparelli V, Norris C, et al.
Medicine (Baltimore)
. 2025 Feb;
104(6):e41021.
PMID: 39928761
While gendered psycho-socio-cultural factors are recognized as major determinants of cardiovascular health, their contribution to our understanding of their effect on hypertension (HTN) in each country is poorly understood. Therefore,...
2.
Pitzen S, Rudenick A, Qiu Y, Zhang W, Munro S, McCluskey B, et al.
Proc Natl Acad Sci U S A
. 2025 Feb;
122(6):e2415308122.
PMID: 39913208
Inhibiting the androgen receptor (AR) is effective for treatment of advanced prostate cancers because of their AR-dependent luminal epithelial cell identity. Tumors progress during therapy to castration-resistant prostate cancer (CRPC)...
3.
Chesner L, Polesso F, Graff J, Hawley J, Smith A, Lundberg A, et al.
Cancer Discov
. 2024 Dec;
15(3):481-494.
PMID: 39652470
Immunotherapy options for immune cold tumors, like prostate cancer, are limited. We show that AR downregulates MHCI expression/antigen presentation and that AR inhibition improves T-cell responses and tumor control. This...
4.
Morel K, German B, Hamid A, Nanda J, Linder S, Bergman A, et al.
J Clin Invest
. 2024 Nov;
135(2.
PMID: 39560993
Phenotypic plasticity is a hallmark of cancer and is increasingly realized as a mechanism of resistance to androgen receptor-targeted (AR-targeted) therapy. Now that many prostate cancer (PCa) patients are treated...
5.
Yavuz S, Kabbech H, van Staalduinen J, Linder S, van Cappellen W, Nigg A, et al.
Nucleic Acids Res
. 2023 Oct;
51(20):10992-11009.
PMID: 37791849
A wide range of nuclear proteins are involved in the spatio-temporal organization of the genome through diverse biological processes such as gene transcription and DNA replication. Upon stimulation by testosterone...
6.
Grillo G, Keshavarzian T, Linder S, Arlidge C, Mout L, Nand A, et al.
Cancer Discov
. 2023 Sep;
13(11):2470-2487.
PMID: 37694973
Significance: We show that oncogenesis relies on co-opting transposable elements from pluripotent stem cells as regulatory elements altering the recruitment of lineage-specific transcription factors. We further discover how co-option is...
7.
Fernandes C, Schaap A, Kant J, van Houdt P, Wijkstra H, Bekers E, et al.
Cancers (Basel)
. 2023 Jun;
15(12).
PMID: 37370685
Prostate cancer (PCa) is a highly prevalent cancer type with a heterogeneous prognosis. An accurate assessment of tumor aggressiveness can pave the way for tailored treatment strategies, potentially leading to...
8.
Linder S, Severson T, van der Mijn K, Nevedomskaya E, Siefert J, Stelloo S, et al.
Eur Urol
. 2023 Jun;
84(5):455-460.
PMID: 37271632
Grade group 1 (GG1) primary prostate cancers with a pathologic Gleason score of 6 are considered indolent and generally not associated with fatal outcomes, so treatment is not indicated for...
9.
Severson T, Zhu Y, Prekovic S, Schuurman K, Nguyen H, Brown L, et al.
medRxiv
. 2023 Mar;
PMID: 36865297
Androgen Receptor (AR) signaling inhibitors, including enzalutamide, are treatment options for patients with metastatic castration-resistant prostate cancer (mCRPC), but resistance inevitably develops. Using metastatic samples from a prospective phase II...
10.
Baca S, Singler C, Zacharia S, Seo J, Morova T, Hach F, et al.
Nat Genet
. 2022 Sep;
54(9):1364-1375.
PMID: 36071171
Many genetic variants affect disease risk by altering context-dependent gene regulation. Such variants are difficult to study mechanistically using current methods that link genetic variation to steady-state gene expression levels,...