Simon J Meek
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Explore the profile of Simon J Meek including associated specialties, affiliations and a list of published articles.
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32
Citations
484
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Recent Articles
1.
Keita H, Meek S
Angew Chem Int Ed Engl
. 2023 Jun;
62(34):e202306277.
PMID: 37350059
A practical method for the preparation of quaternary and tertiary allyl-substituted heteroarenes by site-selective couplings of heteroaryl nitriles and allylic nucleophiles is disclosed. Transformations utilize readily accessible stable reagents, proceed...
2.
Wheatley E, Zanghi J, Mason M, Meek S
Angew Chem Int Ed Engl
. 2023 Jan;
62(18):e202215855.
PMID: 36595272
A practical method for the efficient and enantioselective preparation of versatile ketones and aldehydes that contain an α-quaternary stereocenter is described. Reactions utilize simple carboxylic acid or ester starting materials,...
3.
Marcum J, Meek S
J Am Chem Soc
. 2022 Oct;
144(42):19231-19237.
PMID: 36195082
The enantioselective synthesis of bis-homoallylic alcohols through nickel-catalyzed three-component fragment couplings of simple aldehydes, dienes, and aryl organoborons is disclosed. The reactions proceed through diene dicarbofunctionalization that concurrently forms two...
4.
Wheatley E, Zanghi J, Meek S
Org Lett
. 2020 Nov;
22(23):9269-9275.
PMID: 33206543
A general method for the synthesis of secondary homoallylic alcohols containing α-quaternary carbon stereogenic centers in high diastereo- and enantioselectivity (up to >20:1 dr and >99:1 er) is disclosed. Transformations...
5.
Liang M, Meek S
J Am Chem Soc
. 2020 May;
142(22):9925-9931.
PMID: 32408746
A method for the site-selective and diastereoselective conjugate addition of boron-stabilized allylic nucleophiles to α,β-unsaturated ketones is disclosed. Transformations involve easily prepared γ,γ-disubstituted allyldiboron reagents and proceed in the presence...
6.
Marcum J, Taylor T, Meek S
Angew Chem Int Ed Engl
. 2020 May;
59(33):14070-14075.
PMID: 32374502
A catalytic method for the site-selective and enantioselective synthesis of functionalized arenes by the intermolecular hydroarylation of terminal and internal 1,3-dienes with aryl pinacolato boronates is reported. The reactions are...
7.
Zanghi J, Meek S
Angew Chem Int Ed Engl
. 2020 Feb;
59(22):8451-8455.
PMID: 32101637
A catalytic diastereo- and enantioselective method for the preparation of complex tertiary homoallylic alcohols containing a vicinal quaternary carbon stereogenic center and a versatile alkenylboronic ester is disclosed. Transformations are...
8.
Green J, Zanghi J, Meek S
J Am Chem Soc
. 2020 Jan;
142(4):1704-1709.
PMID: 31934766
A Cu-catalyzed method for the efficient enantio- and diastereoselective synthesis of chiral homoallylic amines bearing a quaternary carbon and an alkenylboron is disclosed. Transformations are promoted by a readily prepared...
9.
Liang M, Meek S
Angew Chem Int Ed Engl
. 2019 Jul;
58(40):14234-14239.
PMID: 31353794
A catalytic enantioselective method for the synthesis of 1,4-keto-alkenylboronate esters by a rhodium-catalyzed conjugate addition pathway is disclosed. A variety of novel, bench-stable alkenyl gem-diboronate esters are synthesized. These easily...
10.
Zanghi J, Liu S, Meek S
Org Lett
. 2019 Jun;
21(13):5172-5177.
PMID: 31199654
A single-pot Cu-catalyzed enantio- and diastereoselective tandem hydroboration/borylative cyclization of alkynes with ketones for the synthesis of carbocycles is reported. The reaction proceeds via desymmetrization and generates four contiguous stereocenters,...