Joseph P A Harrity
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Explore the profile of Joseph P A Harrity including associated specialties, affiliations and a list of published articles.
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82
Citations
355
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Recent Articles
1.
Hoteite L, Allen B, Elhajj M, Meijer A, Harrity J
Chemistry
. 2024 Feb;
30(21):e202400116.
PMID: 38318755
Linearly fused polycyclic piperidines represent common substructures in natural products and biologically active small molecules. We have devised a Pd-catalyzed annulation strategy to these compounds that converts readily available 2-tetralones...
2.
Han J, Gao W, Harrity J
J Org Chem
. 2024 Jan;
89(3):1552-1555.
PMID: 38262918
A Pd-catalyzed formal [4 + 1] cycloaddition reaction of sulfur ylides and in situ-generated Pd-stabilized zwitterions offers a convenient route to a series of functionalized proline derivatives. The utility of...
3.
Gao W, Han J, Greaves S, Harrity J
Org Lett
. 2023 Aug;
25(35):6555-6559.
PMID: 37642309
Peptidomimetics are emerging as a promising class of potent and selective therapeutics. Among the current approaches to these compounds, the utilization of constrained lactams is a key element in enforcing...
4.
Valdez Perez L, Bachollet S, Orlov N, Kopf K, Harrity J
Angew Chem Int Ed Engl
. 2022 Nov;
62(5):e202213692.
PMID: 36377668
We report that axially chiral biaryl boronic esters can be generated with control of atroposelectivity by a Binol-mediated dynamic thermodynamic resolution process. These intermediates can be progressed to enantioenriched products...
5.
Han J, Hoteite L, Harrity J
Chemistry
. 2022 Jul;
28(56):e202201595.
PMID: 35815542
The first useful enantioselective Pd-catalyzed asymmetric allylic alkylation of α-fluoro-β-ketoesters has been achieved using the Trost family of chiral ligands yielding products in up to 92 % ee. This work...
6.
Cousins D, Hwee Lim Y, Harrity J
J Org Chem
. 2022 Jul;
87(15):9764-9768.
PMID: 35802868
The synthesis of perfluoroalkyl-substituted (hetero)arenes by benzannulation strategies is complementary to ring functionalization approaches as it obviates the need for pre-existing functionality and innate regiocontrol. We report a mild and...
7.
Garcia-Vazquez V, Hoteite L, Lakeland C, Watson D, Harrity J
Org Lett
. 2021 Mar;
23(7):2811-2815.
PMID: 33759534
3-Fluoro- and trifluoromethylthio-piperidines represent important building blocks for discovery chemistry. We report a simple and efficient method to access analogs of these compounds that are armed with rich functionality allowing...
8.
Zirimwabagabo J, Jailani A, Avgoustou P, Tozer M, Gibson K, Glossop P, et al.
J Med Chem
. 2021 Mar;
64(6):3299-3319.
PMID: 33666424
Class B G-protein-coupled receptors (GPCRs) remain an underexploited target for drug development. The calcitonin receptor (CTR) family is particularly challenging, as its receptors are heteromers comprising two distinct components: the...
9.
Cousins D, Fricero P, Kopf K, McColl E, Czechtizky W, Hwee Lim Y, et al.
Angew Chem Int Ed Engl
. 2021 Feb;
60(17):9412-9415.
PMID: 33570831
We report a novel and general method to access a highly under-studied privileged scaffold-pyrimidines bearing a trifluoroborate at C4, and highlight the broad utility of these intermediates in a rich...
10.
Mora-Rado H, Czechtizky W, Mendez M, Harrity J
ChemMedChem
. 2020 Nov;
16(2):328-334.
PMID: 33241901
We demonstrate that a diboration-electrocyclization sequence provides access to a range of pyridine-fused, small-molecule boronic ester building blocks, and that these are amenable to high-throughput synthesis leading to biaryl and...