Simon J Meek
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Explore the profile of Simon J Meek including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Goldfogel M, Meek S
Chem Sci
. 2018 Aug;
7(7):4079-4084.
PMID: 30155052
An efficient and diastereoselective (CDC)-Rh-catalyzed hydroalkylation of dienes with 1,3-oxazol-5(4)-ones is reported. Aryl and alkyl substituted dienes are converted to α,α-substituted oxazolones (24 examples) by the formation of -substituted quaternary...
12.
Green J, Joannou M, Murray S, Zanghi J, Meek S
ACS Catal
. 2018 Mar;
7(7):4441-4445.
PMID: 29520326
Catalytic enantioselective synthesis of 1-hydroxy-2,3-bisboronate esters through multicomponent borylation/1,2-addition is reported. Catalyst and substrates are readily available, form both a C-B and C-C bond, and generate up to three contiguous...
13.
Murray S, Luc E, Meek S
Org Lett
. 2018 Jan;
20(2):469-472.
PMID: 29319323
A practical and broadly applicable catalytic method for the synthesis of (E)-alkenylborons is presented. Reactions are promoted by [Pd(Cl)(η-CH)] and proceed by the dehydroboration of cyclic borates. Through the use...
14.
Marcum J, Roberts C, Manan R, Cervarich T, Meek S
J Am Chem Soc
. 2017 Oct;
139(44):15580-15583.
PMID: 29058881
Catalytic enantioselective addition of N-heteroarenes to terminal and internal 1,3-dienes is reported. Reactions are promoted by 5 mol % of Rh catalyst supported by a new chiral pincer carbodicarbene ligand...
15.
Murray S, Liang M, Meek S
J Am Chem Soc
. 2017 Sep;
139(40):14061-14064.
PMID: 28934852
A copper-catalyzed three-component linchpin coupling method for the stereoselective union of readily available epoxides and allyl electrophiles is disclosed. Transformations employ [B(pin)]-methane as a conjunctive reagent, resulting in the formation...
16.
Goldfogel M, Roberts C, Manan R, Meek S
Org Lett
. 2016 Dec;
19(1):90-93.
PMID: 27996276
Catalytic intermolecular hydroalkylation of dienes with silyloxyfuran nucleophiles is reported. Reactions are catalyzed by 5 mol % of a (CDC)-Rh complex and proceed in up to 87% yield and 6:1...
17.
Murray S, Green J, Tailor S, Meek S
Angew Chem Int Ed Engl
. 2016 Jun;
55(31):9065-9.
PMID: 27321039
The catalytic enantioselective synthesis of boronate-substituted tertiary alcohols through additions of diborylmethane and substituted 1,1-diborylalkanes to α-ketoesters is reported. The reactions are catalyzed by readily available chiral phosphine/copper(I) complexes and...
18.
Joannou M, Moyer B, Goldfogel M, Meek S
Angew Chem Int Ed Engl
. 2015 Sep;
54(47):14141-5.
PMID: 26404842
A catalytic protocol for the diastereoselective synthesis of anti-1,2-hydroxyboronates is described. The process provides access to secondary alkyl organoborons. The deborylative 1,2-addition reactions of alkyl 1,1-diborons proceed in the presence...
19.
Roberts C, Matias D, Goldfogel M, Meek S
J Am Chem Soc
. 2015 May;
137(20):6488-91.
PMID: 25961506
The activation of carbodicarbene (CDC)-Rh(I) pincer complexes by secondary binding of metal salts is reported for the catalytic site-selective hydro-heteroarylation of dienes (up to 98% yield and >98:2 γ:α). Reactions...
20.
Joannou M, Moyer B, Meek S
J Am Chem Soc
. 2015 Apr;
137(19):6176-9.
PMID: 25905917
The first catalytic enantio- and diastereoselective synthesis of 1,2-hydroxyboronates is reported. Reactions are promoted by a readily available chiral monodentate phosphoramidite-copper complex in the presence of an alkyl 1,1-diboron reagent....