Simon J Hubbard
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Explore the profile of Simon J Hubbard including associated specialties, affiliations and a list of published articles.
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82
Citations
1983
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Recent Articles
1.
Creamer D, Beynon R, Hubbard S, Ashe M, Grant C
Cell Rep
. 2024 Jun;
43(6):114360.
PMID: 38865242
Protein kinase A (PKA) is a conserved kinase crucial for fundamental biological processes linked to growth, development, and metabolism. The PKA catalytic subunit is expressed as multiple isoforms in diverse...
2.
Ariffin N, Newman D, Nelson M, Ocualain R, Hubbard S
J Proteome Res
. 2024 Apr;
23(5):1583-1592.
PMID: 38651221
MD2 pineapple () is the second most important tropical crop that preserves crassulacean acid metabolism (CAM), which has high water-use efficiency and is fast becoming the most consumed fresh fruit...
3.
Llewellyn J, Hubbard S, Swift J
Trends Cell Biol
. 2024 Feb;
34(8):646-656.
PMID: 38423854
Proteins are molecular machines that provide structure and perform vital transport, signalling and enzymatic roles. Proteins expressed by cells require tight regulation of their concentration, folding, localisation, and modifications; however,...
4.
Kershaw C, Nelson M, Castelli L, Jennings M, Lui J, Talavera D, et al.
J Biol Chem
. 2023 Aug;
299(10):105195.
PMID: 37633333
The regulation of translation provides a rapid and direct mechanism to modulate the cellular proteome. In eukaryotes, an established model for the recruitment of ribosomes to mRNA depends upon a...
5.
Cunningham J, Sfakianos A, Kritsiligkou P, Kershaw C, Whitmarsh A, Hubbard S, et al.
Nucleic Acids Res
. 2023 Jul;
51(16):8820-8835.
PMID: 37449412
Translation initiation factor 4G (eIF4G) is an integral component of the eIF4F complex which is key to translation initiation for most eukaryotic mRNAs. Many eIF4G isoforms have been described in...
6.
Llewellyn J, Mallikarjun V, Appleton E, Osipova M, Gilbert H, Richardson S, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(14):e2210745120.
PMID: 36989307
Cells respond to stress by synthesizing chaperone proteins that seek to correct protein misfolding and maintain function. However, abrogation of protein homeostasis is a hallmark of aging, leading to loss...
7.
Rusilowicz M, Newman D, Creamer D, Johnson J, Adair K, Harman V, et al.
J Proteome Res
. 2023 Jan;
22(2):594-604.
PMID: 36688735
Protein quantitation via mass spectrometry relies on peptide proxies for the parent protein from which abundances are estimated. Owing to the variability in signal from individual peptides, accurate absolute quantitation...
8.
Kan K, Nelson M, Grant C, Hubbard S, Lu H
Int J Mol Sci
. 2022 Nov;
23(22).
PMID: 36430179
Mitochondrial i-AAA proteinase Yme1 is a multifunctional protein that plays important roles in maintaining mitochondrial protein homeostasis and regulating biogenesis and function of mitochondrial proteins. However, due to the complex...
9.
Phillips A, Unwin R, Hubbard S, Dowsey A
Methods Mol Biol
. 2022 Oct;
2426:141-162.
PMID: 36308689
seaMass is an R package for protein-level quantification, normalization, and differential expression analysis of proteomics mass spectrometry data after peptide identification, protein grouping, and feature-level quantification. Using the concept of...
10.
Creamer D, Hubbard S, Ashe M, Grant C
Biomolecules
. 2022 Jul;
12(7).
PMID: 35883514
Eukaryotic cells have developed a complex circuitry of signalling molecules which monitor changes in their intra- and extracellular environments. One of the most widely studied signalling pathways is the highly...