Simon J Atkinson
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Explore the profile of Simon J Atkinson including associated specialties, affiliations and a list of published articles.
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27
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1278
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Recent Articles
1.
Kolb A, Corridon P, Ullah M, Pfaffenberger Z, Xu W, Winfree S, et al.
Biochemistry
. 2024 Aug;
63(18):2310-2322.
PMID: 39194960
Hypothesis: In this communication, we test the hypothesis that sulfotransferase 1C2 (SULT1C2, UniProt accession no. Q9WUW8) can modulate mitochondrial respiration by increasing state-III respiration. Methods And Results: Using freshly isolated...
2.
Dey A, Khedr S, Bean J, Porras L, Meredith T, Willard F, et al.
Front Physiol
. 2020 Oct;
11:543727.
PMID: 33013477
Regulation of the peripheral vascular resistance via modulating the vessel diameter has been considered as a main determinant of the arterial blood pressure. Phosphodiesterase enzymes (PDE1-11) hydrolyse cyclic nucleotides, which...
3.
Atkinson S
J Clin Invest
. 2018 Jun;
128(7):2754-2756.
PMID: 29863496
Acute kidney injury comprises a heterogeneous group of conditions characterized by a sudden decrease in renal function over hours to days. Contrast-induced acute kidney injury (CI-AKI) is caused by radiographic...
4.
Exogenous Gene Transmission of Isocitrate Dehydrogenase 2 Mimics Ischemic Preconditioning Protection
Kolb A, Corridon P, Zhang S, Xu W, Witzmann F, Collett J, et al.
J Am Soc Nephrol
. 2018 Jan;
29(4):1154-1164.
PMID: 29371417
Ischemic preconditioning confers organ-wide protection against subsequent ischemic stress. A substantial body of evidence underscores the importance of mitochondria adaptation as a critical component of cell protection from ischemia. To...
5.
Collett J, Corridon P, Mehrotra P, Kolb A, Rhodes G, Miller C, et al.
J Am Soc Nephrol
. 2017 Jan;
28(7):2081-2092.
PMID: 28122967
Highly aerobic organs like the kidney are innately susceptible to ischemia-reperfusion (I/R) injury, which can originate from sources including myocardial infarction, renal trauma, and transplant. Therapy is mainly supportive and...
6.
Atkinson S
J Clin Invest
. 2016 Apr;
126(5):1640-2.
PMID: 27088799
Acute kidney injury (AKI) is a common cause of hospital-related mortality; therefore, strategies to either prevent or treat this complication are of great interest. In this issue of the JCI,...
7.
Corridon P, Rhodes G, Leonard E, Basile D, Gattone 2nd V, Bacallao R, et al.
Am J Physiol Renal Physiol
. 2013 Mar;
304(9):F1217-29.
PMID: 23467422
Gene therapy has been proposed as a novel alternative to treat kidney disease. This goal has been hindered by the inability to reliably deliver transgenes to target cells throughout the...
8.
Li D, Hallett M, Zhu W, Rubart M, Liu Y, Yang Z, et al.
Development
. 2010 Dec;
138(2):303-15.
PMID: 21177343
Dishevelled-associated activator of morphogenesis 1 (Daam1), a member of the formin protein family, plays an important role in regulating the actin cytoskeleton via mediation of linear actin assembly. Previous functional...
9.
Chen N, Chen X, ONeill K, Atkinson S, Moe S
Am J Physiol Renal Physiol
. 2010 Jul;
299(3):F674-80.
PMID: 20610533
RhoA/Rho kinases (ROCK) play a critical role in vascular smooth muscle cell (VSMC) actin cytoskeleton organization, differentiation, and function and are implicated in the pathogenesis of cardiovascular disease. We have...
10.
Molitoris B, Dagher P, Sandoval R, Campos S, Ashush H, Fridman E, et al.
J Am Soc Nephrol
. 2009 May;
20(8):1754-64.
PMID: 19470675
Proximal tubule cells (PTCs), which are the primary site of kidney injury associated with ischemia or nephrotoxicity, are the site of oligonucleotide reabsorption within the kidney. We exploited this property...