Simon A Rudge
Overview
Explore the profile of Simon A Rudge including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
519
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0
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Recent Articles
1.
Volat F, Medhi R, Maggs L, Deken M, Price A, Andrews L, et al.
Mol Cancer Ther
. 2024 Nov;
24(2):230-241.
PMID: 39570650
Autotaxin (ATX), encoded by ENPP2, is a clinical target in pancreatic ductal adenocarcinoma (PDAC). ATX catalyzes the production of lysophosphatidic acid (LPA), an important regulator within the tumor microenvironment (TME),...
2.
Farquhar M, Humphreys I, Rudge S, Wilson G, Bhattacharya B, Ciaccia M, et al.
J Hepatol
. 2017 Jan;
66(5):919-929.
PMID: 28126468
Background & Aims: Chronic hepatitis C is a global health problem with an estimated 170 million hepatitis C virus (HCV) infected individuals at risk of progressive liver disease and hepatocellular...
3.
Nguyen A, Rudge S, Zhang Q, Wakelam M
Curr Opin Biotechnol
. 2016 Nov;
43:96-103.
PMID: 27816901
Recent advances in lipidomics tools and software assist in the identification and quantification of lipid species detected by mass spectrometry. By integrating mass spectrometric lipid data into mapped pathways and...
4.
Jethwa S, Leah E, Zhang Q, Bright N, Oxley D, Bootman M, et al.
J Cell Sci
. 2016 Aug;
129(20):3948-3957.
PMID: 27557622
Autotaxin (ATX; also known as ENPP2), the lysophospholipase responsible for generating the lipid receptor agonist lysophosphatidic acid (LPA), is a secreted enzyme. Here we show that, once secreted, ATX can...
5.
Rudge S, Wakelam M
J Lipid Res
. 2015 Aug;
57(2):176-92.
PMID: 26302980
Signaling through the phosphoinositide 3-kinase pathways mediates the actions of a plethora of hormones, growth factors, cytokines, and neurotransmitters upon their target cells following receptor occupation. Overactivation of these pathways...
6.
Rohwedder A, Zhang Q, Rudge S, Wakelam M
J Cell Sci
. 2014 May;
127(Pt 14):3104-15.
PMID: 24876224
It is unclear how changes in lipid droplet size and number are regulated - for example, it is not known whether this involves a signalling pathway or is directed by...
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Pal A, Barber T, van de Bunt M, Rudge S, Zhang Q, Lachlan K, et al.
N Engl J Med
. 2012 Sep;
367(11):1002-11.
PMID: 22970944
Background: Epidemiologic and genetic evidence links type 2 diabetes, obesity, and cancer. The tumor-suppressor phosphatase and tensin homologue (PTEN) has roles in both cellular growth and metabolic signaling. Germline PTEN...
10.
Norton L, Zhang Q, Saqib K, Schrewe H, Macura K, Anderson K, et al.
J Cell Sci
. 2011 May;
124(Pt 12):1973-83.
PMID: 21610093
The signalling lipid phosphatidic acid (PA) is generated by the hydrolysis of phosphatidylcholine (PC), which is catalysed by phospholipase D (PLD) enzymes. Neutrophils, important cells of the innate immune system,...