Simeon E Goldblum
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Explore the profile of Simeon E Goldblum including associated specialties, affiliations and a list of published articles.
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41
Citations
1086
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Recent Articles
11.
Tiper I, Temkin S, Spiegel S, Goldblum S, Giuntoli 2nd R, Oelke M, et al.
Clin Cancer Res
. 2016 Apr;
22(16):4249-58.
PMID: 27076627
Purpose: Natural killer T (NKT) cells are important mediators of antitumor immune responses. We have previously shown that ovarian cancers shed the ganglioside GD3, which inhibits NKT-cell activation. Ovarian cancers...
12.
Luzina I, Lockatell V, Hyun S, Kopach P, Kang P, Noor Z, et al.
Am J Physiol Lung Cell Mol Physiol
. 2016 Mar;
310(10):L940-54.
PMID: 26993524
Idiopathic pulmonary fibrosis (IPF) poses challenges to understanding its underlying cellular and molecular mechanisms and the development of better therapies. Previous studies suggest a pathophysiological role for neuraminidase 1 (NEU1),...
13.
Lillehoj E, Hyun S, Liu A, Guang W, Verceles A, Luzina I, et al.
J Biol Chem
. 2015 May;
290(30):18316-31.
PMID: 25963144
Airway epithelia express sialylated receptors that recognize exogenous danger signals. Regulation of receptor responsiveness to these signals remains incompletely defined. Here, we explore the mechanisms through which the human sialidase,...
14.
Miranda-Ribera A, Passaniti A, Ceciliani F, Goldblum S
Exp Lung Res
. 2014 Oct;
40(10):507-19.
PMID: 25322067
Purpose: The acute phase protein, α1-acid glycoprotein, is expressed in the lung, and influences endothelial cell function. We asked whether it might regulate angiogenesis in human lung microvascular endothelia. Materials...
15.
Lillehoj E, Hyun S, Feng C, Zhang L, Liu A, Guang W, et al.
Am J Physiol Lung Cell Mol Physiol
. 2014 Mar;
306(9):L876-86.
PMID: 24658138
Sialic acids on glycoconjugates play a pivotal role in many biological processes. In the airways, sialylated glycoproteins and glycolipids are strategically positioned on the plasma membranes of epithelia to regulate...
16.
Lee C, Liu A, Miranda-Ribera A, Hyun S, Lillehoj E, Cross A, et al.
J Biol Chem
. 2014 Feb;
289(13):9121-35.
PMID: 24550400
The highly sialylated vascular endothelial surface undergoes changes in sialylation upon adopting the migratory/angiogenic phenotype. We recently established endothelial cell (EC) expression of NEU1 sialidase (Cross, A. S., Hyun, S....
17.
Feng C, Zhang L, Nguyen C, Vogel S, Goldblum S, Blackwelder W, et al.
J Immunol
. 2013 Sep;
191(9):4828-37.
PMID: 24068662
We previously reported that removal of sialyl residues primed PBMCs to respond to bacterial LPS stimulation in vitro. Therefore, we speculated that prior desialylation can sensitize the host to generate...
18.
Shah N, Tulapurkar M, Damarla M, Singh I, Goldblum S, Shapiro P, et al.
Int J Hyperthermia
. 2012 Jul;
28(7):627-35.
PMID: 22834633
Fever commonly occurs in acute lung injury (ALI) and ALI occurs in 25% of victims of heat stroke. We have shown in mouse models of ALI that exposure to febrile-range...
19.
Liu A, Gong P, Hyun S, Wang K, Cates E, Perkins D, et al.
J Biol Chem
. 2012 Mar;
287(20):16132-45.
PMID: 22447928
Gram-negative bacteria release lipopolysaccharide (LPS) into the bloodstream. Here, it engages Toll-like receptor (TLR) 4 expressed in human lung microvascular endothelia (HMVEC-Ls) to open the paracellular pathway through Src family...
20.
Cross A, Hyun S, Miranda-Ribera A, Feng C, Liu A, Nguyen C, et al.
J Biol Chem
. 2012 Mar;
287(19):15966-80.
PMID: 22403397
The microvascular endothelial surface expresses multiple molecules whose sialylation state regulates multiple aspects of endothelial function. To better regulate these sialoproteins, we asked whether endothelial cells (ECs) might express one...