Simeon E Goldblum
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Explore the profile of Simeon E Goldblum including associated specialties, affiliations and a list of published articles.
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41
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1086
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Recent Articles
1.
Lillehoj E, Yu Y, Verceles A, Imamura A, Ishida H, Piepenbrink K, et al.
iScience
. 2024 Sep;
27(9):110866.
PMID: 39314239
(Sm), a multidrug-resistant pathogen often isolated from immunocompromised individuals, presents its flagellin to multimeric tandem repeats within the ectodomain of mucin-1 (MUC1-ED), expressed on airway epithelia. Flagellated Sm increases neuraminidase-1...
2.
Hyun S, Feng C, Liu A, Lillehoj E, Trotta R, Kingsbury T, et al.
Sci Rep
. 2022 Aug;
12(1):14173.
PMID: 35986080
To gain insight into sialic acid biology and sialidase/neuraminidase (NEU) expression in mature human neutrophil (PMN)s, we studied NEU activity and expression in PMNs and the HL60 promyelocytic leukemic cell...
3.
Verceles A, Bhat P, Nagaria Z, Martin D, Patel H, Ntem-Mensah A, et al.
Sci Rep
. 2021 Nov;
11(1):22725.
PMID: 34811449
We previously reported that flagellin-expressing Pseudomonas aeruginosa (Pa) provokes NEU1 sialidase-mediated MUC1 ectodomain (MUC1-ED) desialylation and MUC1-ED shedding from murine lungs in vivo. Here, we asked whether Pa in the...
4.
Hyun S, Imamura A, Ishida H, Piepenbrink K, Goldblum S, Lillehoj E
J Biol Chem
. 2021 Oct;
297(5):101337.
PMID: 34688655
The extracellular domain (ED) of the membrane-spanning sialoglycoprotein, mucin-1 (MUC1), is an in vivo substrate for the lysosomal sialidase, neuraminidase-1 (NEU1). Engagement of the MUC1-ED by its cognate ligand, Pseudomonas...
5.
Luzina I, Lillehoj E, Lockatell V, Hyun S, Lugkey K, Imamura A, et al.
J Pharmacol Exp Ther
. 2020 Nov;
376(1):136-146.
PMID: 33139318
Pulmonary fibrosis remains a serious biomedical problem with no cure and an urgent need for better therapies. Neuraminidases (NEUs), including NEU1, have been recently implicated in the mechanism of pulmonary...
6.
Lillehoj E, Guang W, Hyun S, Liu A, Hegerle N, Simon R, et al.
J Biol Chem
. 2018 Nov;
294(2):662-678.
PMID: 30429216
(Pa) expresses an adhesin, flagellin, that engages the mucin 1 (MUC1) ectodomain (ED) expressed on airway epithelia, increasing association of MUC1-ED with neuraminidase 1 (NEU1) and MUC1-ED desialylation. The MUC1-ED...
7.
Feng C, Li J, Snyder G, Huang W, Goldblum S, Chen W, et al.
mBio
. 2017 Jun;
8(3).
PMID: 28655817
Neuraminidases (NAs) are critical virulence factors for several microbial pathogens. With a highly conserved catalytic domain, a microbial NA "superfamily" has been proposed. We previously reported that murine polymorphonuclear leukocyte...
8.
Hyun S, Liu A, Liu Z, Lillehoj E, Madri J, Reynolds A, et al.
Cell Signal
. 2017 Mar;
35:1-15.
PMID: 28343945
In postconfluent human pulmonary microvascular endothelial cell (HPMEC)s, NEU1 sialidase associates with and desialylates the src family kinase (SFK) substrate, CD31, and disrupts angiogenesis. We asked whether the NEU1-CD31 interaction...
9.
Piepenbrink K, Lillehoj E, Harding C, Labonte J, Zuo X, Rapp C, et al.
J Biol Chem
. 2016 Sep;
291(44):22924-22935.
PMID: 27634041
Acinetobacter baumannii is a Gram-negative coccobacillus found primarily in hospital settings that has recently emerged as a source of hospital-acquired infections. A. baumannii expresses a variety of virulence factors, including...
10.
Hyun S, Liu A, Liu Z, Cross A, Verceles A, Magesh S, et al.
Glycobiology
. 2016 May;
26(8):834-49.
PMID: 27226251
Neuraminidase-1 (NEU1) is the predominant sialidase expressed in human airway epithelia and lung microvascular endothelia where it mediates multiple biological processes. We tested whether the NEU1-selective sialidase inhibitor, C9-butyl-amide-2-deoxy-2,3-dehydro-N-acetylneuraminic acid...