Silva Mulhovo
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Explore the profile of Silva Mulhovo including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
288
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Recent Articles
1.
Bharathiraja P, Cardoso D, Prasad N, Mulhovo S, Lakra D, Ferreira M
J Biochem Mol Toxicol
. 2023 Jun;
37(9):e23421.
PMID: 37345739
Multidrug resistance (MDR) remains a significant challenge in cancer chemotherapy due to the overexpression of ATP-binding cassette drug-efflux transporters, namely P-glycoprotein (P-gp)/ATP-binding cassette subfamily B member 1. In this study,...
2.
Silva C, Ramalhete C, Spengler G, Mulhovo S, Molnar J, Ferreira M
Phytochemistry
. 2022 Aug;
203:113354.
PMID: 35940427
Aiming at overcoming multidrug resistance (MDR) in cancer, we have been studying Momordica balsamina, a vegetable known as African pumpkin. Five undescribed cucurbitane-type triterpenoids (balsaminaepoxide, balsaminatriol, balsaminoic acid, balsaminal, and...
3.
Cardoso D, Szemeredi N, Spengler G, Mulhovo S, Dos Santos D, Ferreira M
Pharmaceuticals (Basel)
. 2021 Sep;
14(9).
PMID: 34577562
Dregamine (), a major monoterpene indole alkaloid isolated from was submitted to chemical transformation of the ketone function, yielding 19 azines (-) and 11 semicarbazones (-) bearing aliphatic or aromatic...
4.
Raimundo L, Paterna A, Calheiros J, Ribeiro J, Cardoso D, Piga I, et al.
Br J Pharmacol
. 2021 Apr;
178(18):3627-3647.
PMID: 33899955
Background And Purpose: Advances in the treatment of triple-negative breast and ovarian cancer remain challenging. In particular, resistance to the available therapy, by restoring or overexpressing the DNA repair machinery,...
5.
Cardoso D, Kincses A, Nove M, Spengler G, Mulhovo S, Aires-de-Sousa J, et al.
Eur J Med Chem
. 2020 Nov;
210:112985.
PMID: 33189435
Aiming at generating a series of monoterpene indole alkaloids with enhanced multidrug resistance (MDR) reversing activity in cancer, two major epimeric alkaloids isolated from Tabernaemontana elegans, tabernaemontanine (1) and dregamine...
6.
Monico A, Ramalhete C, Andre V, Spengler G, Mulhovo S, Duarte M, et al.
J Nat Prod
. 2019 Jul;
82(8):2138-2143.
PMID: 31339732
Three new triterpenoids, cucurbalsaminones A-C (-), featuring a unique 5/6/3/6/5-fused pentacyclic carbon skeleton, named cucurbalsaminane, were isolated from a methanol extract of . Their structures were elucidated by spectroscopic methods...
7.
Ramalhete C, Mulhovo S, Lage H, Ferreira M
Planta Med
. 2018 Jul;
84(18):1372-1379.
PMID: 29996165
The collateral sensitivity effect is among the most promising strategies for overcoming multidrug resistance in cancer. In this work, 28 cucurbitane-type triterpenoids (1: -28: ), previously isolated from the African...
8.
Kincses A, Varga B, Csonka A, Sancha S, Mulhovo S, Madureira A, et al.
Phytother Res
. 2018 Feb;
32(6):1039-1046.
PMID: 29464798
Cleistochlamys kirkii (Benth) Oliv. (Annonaceae) is a medicinal plant traditionally used in Mozambique to treat infectious diseases. The aim of this study was to find resistance modifiers in C. kirkii...
9.
Paterna A, Khonkarn R, Mulhovo S, Moreno A, Madeira Girio P, Baubichon-Cortay H, et al.
Bioorg Med Chem
. 2017 Dec;
26(2):421-434.
PMID: 29233614
Aiming at generating a library of bioactive indole alkaloid derivatives as multidrug resistance (MDR) reversers, two epimeric indole alkaloids (1 and 2) were submitted to chemical transformations, giving rise to...
10.
Paterna A, Kincses A, Spengler G, Mulhovo S, Molnar J, Ferreira M
Eur J Med Chem
. 2017 Feb;
128:247-257.
PMID: 28189906
Dregamine (1) and tabernaemontanine (2), two epimeric monoterpene indole alkaloids isolated in large amount from the roots of the African plant Tabernaemontana elegans, were derivatized, yielding ten imine derivatives, as...