Sijiu Liu
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Explore the profile of Sijiu Liu including associated specialties, affiliations and a list of published articles.
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26
Citations
685
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Recent Articles
1.
He R, Wang J, Yu Z, Zhang R, Liu S, Wu L, et al.
J Med Chem
. 2016 Sep;
59(19):9094-9106.
PMID: 27676368
The low molecular weight protein tyrosine phosphatase (LMW-PTP) is a regulator of a number of signaling pathways and has been implicated as a potential target for oncology and diabetes/obesity. There...
2.
Bai Y, Yu Z, Liu S, Zhang L, Zhang R, Zeng L, et al.
Cancer Res
. 2016 Jun;
76(16):4805-15.
PMID: 27325652
Phosphatase of regenerating liver (PRL) oncoproteins are phosphatases overexpressed in numerous types of human cancer. Elevated levels of PRL associate with metastasis and poor clinical outcomes. In principle, PRL phosphatases...
3.
Yu Z, Zhang R, Walls C, Chen L, Zhang S, Wu L, et al.
Biochemistry
. 2014 Jun;
53(25):4136-51.
PMID: 24935154
The Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 2 (SHP2) is a critical signal transducer downstream of growth factors that promotes the activation of the RAS-ERK1/2 cascade. In its...
4.
He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan A, et al.
J Med Chem
. 2013 May;
56(12):4990-5008.
PMID: 23713581
Lymphoid-specific tyrosine phosphatase (LYP), a member of the protein tyrosine phosphatase (PTP) family of signaling enzymes, is associated with a broad spectrum of autoimmune diseases. Herein we describe our structure-based...
5.
Yu Z, Xu J, Walls C, Chen L, Zhang S, Zhang R, et al.
J Biol Chem
. 2013 Mar;
288(15):10472-82.
PMID: 23457302
SHP2 is an allosteric phosphatase essential for growth factor-mediated Ras activation. Germ-line mutations in SHP2 cause clinically similar LEOPARD and Noonan syndromes, two of several autosomal-dominant conditions characterized by gain-of-function...
6.
Zhang S, Liu S, Tao R, Wei D, Chen L, Shen W, et al.
J Am Chem Soc
. 2012 Oct;
134(43):18116-24.
PMID: 23075115
Protein tyrosine phosphatases (PTPs) constitute a large family of signaling enzymes that control the cellular levels of protein tyrosine phosphorylation. A detailed understanding of PTP functions in normal physiology and...
7.
He Y, Zeng L, Yu Z, He R, Liu S, Zhang Z
Bioorg Med Chem
. 2011 Dec;
20(6):1940-6.
PMID: 22133902
Protein tyrosine phosphatases (PTPs) constitute a large and structurally diverse family of signaling enzymes that control the cellular levels of protein tyrosine phosphorylation. Malfunction of PTP activity has significant implications...
8.
Bai Y, Luo Y, Liu S, Zhang L, Shen K, Dong Y, et al.
J Biol Chem
. 2011 Oct;
286(49):42316-42324.
PMID: 22009749
Phosphatases of the regenerating liver (PRL) play oncogenic roles in cancer development and metastasis. Although previous studies indicate that PRL-1 promotes cell growth and migration by activating both the ERK1/2...
9.
Yu X, Chen M, Zhang S, Yu Z, Sun J, Wang L, et al.
J Biol Chem
. 2011 Jul;
286(35):30526-30534.
PMID: 21719704
A missense single-nucleotide polymorphism in the gene encoding the lymphoid-specific tyrosine phosphatase (Lyp) has been identified as a causal factor in a wide spectrum of autoimmune diseases. Interestingly, the autoimmune-predisposing...
10.
Yu Z, Chen L, Wu L, Liu S, Wang L, Zhang Z
Bioorg Med Chem Lett
. 2011 Jun;
21(14):4238-42.
PMID: 21669525
SHP2, encoded by PTPN11, is a non-receptor protein tyrosine phosphatase (PTP) containing two tandem Src homology-2 (SH2) domains. It is expressed ubiquitously and plays critical roles in growth factor mediated...