Sigrun Hage
Overview
Explore the profile of Sigrun Hage including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
201
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Recent Articles
11.
Alkhashrom S, Kicuntod J, Hage S, Schweininger J, Muller Y, Lischka P, et al.
Viruses
. 2021 Apr;
13(3).
PMID: 33809234
Nuclear egress is an essential process in the replication of human cytomegalovirus (HCMV), as it enables the migration of newly formed viral capsids from the nucleus into the cytoplasm. Inhibition...
12.
Kicuntod J, Alkhashrom S, Hage S, Diewald B, Muller R, Hahn F, et al.
Viruses
. 2021 Apr;
13(3).
PMID: 33799898
Herpesviral nuclear egress is a regulated process shared by all family members, ensuring the efficient cytoplasmic release of viral capsids. In the case of human cytomegalovirus (HCMV), the core of...
13.
Hage S, Sonntag E, Svrlanska A, Borst E, Stilp A, Horsch D, et al.
Viruses
. 2021 Jan;
13(2).
PMID: 33499341
Nuclear egress is a common herpesviral process regulating nucleocytoplasmic capsid release. For human cytomegalovirus (HCMV), the nuclear egress complex (NEC) is determined by the pUL50-pUL53 core that regulates multicomponent assembly...
14.
Hahn F, Wangen C, Hage S, Peter A, Dobler G, Hurst B, et al.
Viruses
. 2020 Dec;
12(12).
PMID: 33291455
The ongoing pandemic spread of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) demands skillful strategies for novel drug development, drug repurposing and cotreatments, in particular focusing on existing...
15.
Marschall M, Hage S, Conrad M, Alkhashrom S, Kicuntod J, Schweininger J, et al.
Viruses
. 2020 Jul;
12(6).
PMID: 32599939
Herpesviruses uniquely express two essential nuclear egress-regulating proteins forming a heterodimeric nuclear egress complex (core NEC). These core NECs serve as hexameric lattice-structured platforms for capsid docking and recruit viral...
16.
Hage S, Horsch D, Stilp A, Kicuntod J, Muller R, Hamilton S, et al.
J Virol Methods
. 2020 Jun;
283:113909.
PMID: 32544419
Nuclear egress is a rate-limiting step of herpesviral replication, restricting the nucleocytoplasmic transport of viral capsids. The process is regulated by two viral nuclear egress proteins (core NEC pUL50-pUL53), which...
17.
Hage S, Sonntag E, Borst E, Tannig P, Seyler L, Bauerle T, et al.
Viruses
. 2020 Mar;
12(3).
PMID: 32168891
Nuclear egress is a regulated process shared by α-, β- and γ-herpesviruses. The core nuclear egress complex (NEC) is composed of the membrane-anchored protein homologs of human cytomegalovirus (HCMV) pUL50,...
18.
Muller Y, Hage S, Alkhashrom S, Hollriegl T, Weigert S, Dolles S, et al.
J Biol Chem
. 2020 Jan;
295(10):3189-3201.
PMID: 31980459
Herpesviruses uniquely express two essential nuclear egress-regulating proteins forming a heterodimeric basic structure of the nuclear egress complex (core NEC). These core NECs serve as a hexameric lattice-structured platform for...
19.
Sonntag E, Milbradt J, Svrlanska A, Strojan H, Hage S, Kraut A, et al.
J Gen Virol
. 2017 Sep;
98(10):2569-2581.
PMID: 28949903
Nuclear egress of herpesvirus capsids is mediated by a multi-component nuclear egress complex (NEC) assembled by a heterodimer of two essential viral core egress proteins. In the case of human...