Si-Cheng Liang
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Explore the profile of Si-Cheng Liang including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
138
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Recent Articles
1.
Zhu L, Chen L, Bai C, Wu A, Liang S, Huang F, et al.
Biomed Pharmacother
. 2019 Dec;
123:109756.
PMID: 31864212
Ziyuglycoside I (ZgI), one of the main active ingredients in the popular Diyushengbai tablet made from Sanguisorba officinalis L., has been proven to relieve leukopenia clinically. However, to our knowledge,...
2.
Liang S, Ge G, Xia Y, Qi X, Wang A, Tu C, et al.
Yao Xue Xue Bao
. 2018 Jul;
52(2):291-5.
PMID: 29979523
Daphnetin is quickly eliminated in rats after dosing, but the mechanism remains unclear. This
study was aimed to investigate the in vitro metabolism of daphnetin using rat liver S9 fractions...
3.
Liang S, Ge G, Xia Y, Pei-Pei D, Ping W, Qi X, et al.
Xenobiotica
. 2016 Jul;
47(6):498-504.
PMID: 27435571
1. Finding and developing inhibitors of catechol-O-methyltransferase (COMT) from natural products is highly recommended. Daphnetin, a naturally occurring catechol from the family thymelaeaceae, has a chemical structure similar to several...
4.
Liang S, Xia Y, Hou J, Ge G, Zhang J, He Y, et al.
J Pharm Sci
. 2016 Feb;
105(2):808-816.
PMID: 26869431
Our previous study demonstrated that daphnetin is subject to glucuronidation in vitro. However, daphnetin metabolism is still poorly documented. This study aimed to investigate daphnetin metabolism and its consequent effect...
5.
Liang S, Ge G, Xia Y, Zhang J, Qi X, Tu C, et al.
J Pharm Sci
. 2015 Jun;
104(10):3557-64.
PMID: 26104686
The C-8 phenol group is essential to exert the bioactivities of daphnetin, but it is readily conjugated with glucuronic acid prior to excretion. In this study, daphnetin-7-methylether (7M-DNP) was used...
6.
Jiang L, Liang S, Wang C, Ge G, Huo X, Qi X, et al.
Sci Rep
. 2015 Apr;
5:9627.
PMID: 25884245
Glucuronidation mediated by uridine 5'-diphospho (UDP)-glucuronosyltransferase is an important detoxification pathway. However, identifying a selective probe of UDP- glucuronosyltransferase is complicated because of the significant overlapping substrate specificity displayed by...
7.
Xia Y, Ge G, Wang P, Liang S, He Y, Ning J, et al.
Drug Metab Dispos
. 2015 Jan;
43(4):553-60.
PMID: 25626951
Esculetin (6,7-dihydroxycoumarin) and its C-4 derivatives have multiple pharmacologic activities, but the poor metabolic stability of these catechols has severely restricted their application in the clinic. Glucuronidation plays important roles...
8.
Xia Y, Liang S, Zhu L, Ge G, He G, Ning J, et al.
Drug Metab Pharmacokinet
. 2013 Sep;
29(2):135-40.
PMID: 24025985
Fraxetin, a major constituent of the traditional medicine plant Fraxinus rhynchophylla Hance (Oleaceae), has been found to possess multiple bioactivities. However, the metabolic pathway(s) of fraxetin in human tissues has...
9.
Qi X, Liang S, Ge G, Liu Y, Dong P, Zhang J, et al.
Food Chem Toxicol
. 2013 Mar;
56:392-7.
PMID: 23500771
Sanguinarine (SAG) has been recognized as an anticancer drug candidate. However, the drug-drug interactions (DDI) potential for SAG via the inhibition against human cytochrome P450 (CYP) enzymes remains unclear. In...
10.
Ge G, Ai C, Hu W, Hou J, Zhu L, He G, et al.
Eur J Pharm Sci
. 2012 Dec;
48(1-2):360-9.
PMID: 23220486
Boc5, the first nonpeptidic agonist of Glucagon-like peptide-1 receptor, has been recognized as a potential candidate for treatment of diabetes. However, the metabolic behaviors of this novel molecule in both...