Shyun Li
Overview
Explore the profile of Shyun Li including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
15
Citations
947
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Deegen P, Thomas O, Nolan-Stevaux O, Li S, Wahl J, Bogner P, et al.
Clin Cancer Res
. 2021 Jan;
27(10):2928-2937.
PMID: 33504551
Purpose: Metastatic castration-resistant prostate cancer (mCRPC) remains a disease with high unmet medical need, as most patients do not achieve durable response with available treatments. Prostate-specific membrane antigen (PSMA) is...
2.
Rex K, Jeffries S, Brown M, Carlson T, Coxon A, Fajardo F, et al.
PLoS One
. 2013 Jul;
8(7):e68328.
PMID: 23861887
Sphingosine kinases (SPHKs) are enzymes that phosphorylate the lipid sphingosine, leading to the formation of sphingosine-1-phosphate (S1P). In addition to the well established role of extracellular S1P as a mitogen...
3.
Gustin D, Li Y, Brown M, Min X, Schmitt M, Wanska M, et al.
Bioorg Med Chem Lett
. 2013 Jul;
23(16):4608-16.
PMID: 23845219
Sphingosine-1-phosphate (S1P) signaling plays a vital role in mitogenesis, cell migration and angiogenesis. Sphingosine kinases (SphKs) catalyze a key step in sphingomyelin metabolism that leads to the production of S1P....
4.
Wesche H, Henzel W, Shillinglaw W, Li S, Cao Z
J Immunol
. 2012 Dec;
190(1):5-15.
PMID: 23264669
No abstract available.
5.
Jiao X, Kopecky D, Liu J, Liu J, Jaen J, Cardozo M, et al.
Bioorg Med Chem Lett
. 2012 Aug;
22(19):6212-7.
PMID: 22929232
Two classes of ACK1 inhibitors, 4,5,6-trisubstituted furo[2,3-d]pyrimidin4-amines and 4,5,6-trisubstituted 7H-pyrrolo[2,3-d]pyrimidin-4-amines, were discovered and evaluated as ACK1 inhibitors. Further structural refinement led to the identification of potent and selective dithiolane inhibitor...
6.
Chen X, Kopecky D, Mihalic J, Jeffries S, Min X, Heath J, et al.
J Med Chem
. 2012 Mar;
55(8):3837-51.
PMID: 22458568
The eukaryotic initiation factor 4E (eIF4E) plays a central role in the initiation of gene translation and subsequent protein synthesis by binding the 5' terminal mRNA cap structure. We designed...
7.
Kopecky D, Hao X, Chen Y, Fu J, Jiao X, Jaen J, et al.
Bioorg Med Chem Lett
. 2008 Nov;
18(24):6352-6.
PMID: 18993068
A new series of pyrazolo[3,4-d]pyrimidine-3,6-diamines was designed and synthesized as potent and selective inhibitors of the nonreceptor tyrosine kinase, ACK1. These compounds arose from efforts to rigidify an earlier series...
8.
van der Horst E, Frank B, Chinn L, Coxon A, Li S, Polesso F, et al.
Neoplasia
. 2008 Apr;
10(4):340-7.
PMID: 18392135
Midkine (MDK) is a heparin-binding growth factor involved in growth, survival, migration, and differentiation of various target cells and dysregulation of MDK signaling is implicated in a variety of inflammatory...
9.
Xiao S, Farrelly E, Anzola J, Crawford D, Jiao X, Liu J, et al.
Anal Biochem
. 2007 Jun;
367(2):179-89.
PMID: 17592719
Several drugs inhibiting protein kinases have been launched successfully, demonstrating the attractiveness of protein kinases as therapeutic targets. Functional genomics research within both academia and industry has led to the...
10.
Wang Z, Liu J, Sudom A, Ayres M, Li S, Wesche H, et al.
Structure
. 2006 Dec;
14(12):1835-44.
PMID: 17161373
Interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4) is a serine/threonine kinase that plays an essential role in signal transduction by Toll/IL-1 receptors (TIRs). Here, we report the crystal structures of the phosphorylated...