Shawn Jeffries
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Explore the profile of Shawn Jeffries including associated specialties, affiliations and a list of published articles.
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11
Citations
1041
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Recent Articles
1.
Singh S, Serwer L, DuPage A, Elkins K, Chauhan N, Ravn M, et al.
Mol Cancer Ther
. 2022 Jun;
21(8):1326-1336.
PMID: 35666803
Probody therapeutics (Pb-Txs) are conditionally activated antibody-drug conjugates (ADCs) designed to remain inactive until proteolytically activated in the tumor microenvironment, enabling safer targeting of antigens expressed in both tumor and...
2.
Jin K, Zhou W, Han X, Wang Z, Li B, Jeffries S, et al.
Cancer Res
. 2017 Jun;
77(16):4228-4237.
PMID: 28625977
Although it has long been appreciated that p300 acts as a critical Notch coactivator, the mechanistic details of p300 in Notch-mediated transcription remain unclear. We previously demonstrated that PEAK1-related kinase...
3.
Rex K, Jeffries S, Brown M, Carlson T, Coxon A, Fajardo F, et al.
PLoS One
. 2013 Jul;
8(7):e68328.
PMID: 23861887
Sphingosine kinases (SPHKs) are enzymes that phosphorylate the lipid sphingosine, leading to the formation of sphingosine-1-phosphate (S1P). In addition to the well established role of extracellular S1P as a mitogen...
4.
Gustin D, Li Y, Brown M, Min X, Schmitt M, Wanska M, et al.
Bioorg Med Chem Lett
. 2013 Jul;
23(16):4608-16.
PMID: 23845219
Sphingosine-1-phosphate (S1P) signaling plays a vital role in mitogenesis, cell migration and angiogenesis. Sphingosine kinases (SphKs) catalyze a key step in sphingomyelin metabolism that leads to the production of S1P....
5.
Chen X, Kopecky D, Mihalic J, Jeffries S, Min X, Heath J, et al.
J Med Chem
. 2012 Mar;
55(8):3837-51.
PMID: 22458568
The eukaryotic initiation factor 4E (eIF4E) plays a central role in the initiation of gene translation and subsequent protein synthesis by binding the 5' terminal mRNA cap structure. We designed...
6.
Guimaraes C, Kopecky D, Mihalic J, Shen S, Jeffries S, Thibault S, et al.
J Am Chem Soc
. 2009 Nov;
131(50):18139-46.
PMID: 19924990
Eukaryotic mRNAs are appended at the 5' end, with the 7-methylguanosine cap linked by a 5'-5'-triphosphate bridge to the first transcribed nucleoside (m7GpppX). Initiation of cap-dependent translation of mRNA requires...
7.
Ely A, Banitt A, Befort C, Hou Q, Rhode P, Grund C, et al.
J Rural Health
. 2008 Apr;
24(2):125-32.
PMID: 18397445
Context: Obesity is a chronic disease of epidemic proportions in the United States. Primary care providers are critical to timely diagnosis and treatment of obesity, and need better tools to...
8.
Koo S, Flechner L, Qi L, Zhang X, Screaton R, Jeffries S, et al.
Nature
. 2005 Sep;
437(7062):1109-11.
PMID: 16148943
Glucose homeostasis is regulated systemically by hormones such as insulin and glucagon, and at the cellular level by energy status. Glucagon enhances glucose output from the liver during fasting by...
9.
Screaton R, Conkright M, Katoh Y, Best J, Canettieri G, Jeffries S, et al.
Cell
. 2004 Sep;
119(1):61-74.
PMID: 15454081
Elevations in circulating glucose and gut hormones during feeding promote pancreatic islet cell viability in part via the calcium- and cAMP-dependent activation of the transcription factor CREB. Here, we describe...
10.
Jeffries S, Robbins D, Capobianco A
Mol Cell Biol
. 2002 May;
22(11):3927-41.
PMID: 11997524
Notch genes encode a family of transmembrane proteins that are involved in many cellular processes, such as differentiation, proliferation, and apoptosis. It is well established that all four Notch genes...