Shuhei Kotoshiba
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Explore the profile of Shuhei Kotoshiba including associated specialties, affiliations and a list of published articles.
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10
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554
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Recent Articles
1.
Kotoshiba S, Gopinathan L, Pfeiffenberger E, Rahim A, Vardy L, Nakayama K, et al.
Biochim Biophys Acta
. 2013 Nov;
1843(2):436-45.
PMID: 24269842
Cyclin-dependent kinase 2 (Cdk2) is dispensable for mitotic cell cycle progression and Cdk2 knockout mice are viable due to the compensatory functions of other Cdks. In order to assess the...
2.
Li W, Kotoshiba S, Kaldis P
Transgenic Res
. 2009 May;
18(4):491-8.
PMID: 19418238
Early studies on cell cycle regulation were based on experiments in model systems (Yeast, Xenopus, Starfish, Drosophila) and have shaped the way we understand many events that control the cell...
3.
Li W, Kotoshiba S, Berthet C, Hilton M, Kaldis P
Proc Natl Acad Sci U S A
. 2009 Jan;
106(2):486-91.
PMID: 19129496
The G(1)/S-phase transition is a well-toned switch in the mammalian cell cycle. Cdk2, Cdk4, and the rate-limiting tumor suppressor retinoblastoma protein (Rb) have been studied in separate animal models, but...
4.
Tsunematsu R, Nishiyama M, Kotoshiba S, Saiga T, Kamura T, Nakayama K
Mol Cell Biol
. 2006 Aug;
26(16):6157-69.
PMID: 16880526
Cullin-based ubiquitin ligases (E3s) constitute one of the largest E3 families. Fbxw8 (also known as Fbw6 or Fbx29) is an F-box protein that is assembled with Cul7 in an SCF-like...
5.
Kobayashi N, Iwakami K, Kotoshiba S, Niwa T, Kato Y, Mano N, et al.
Anal Chem
. 2006 Apr;
78(7):2244-53.
PMID: 16579604
To overcome the sensitivity limit in immunoassays for small molecules (haptens), we established a noncompetitive immunoenzymometric assay (IEMA) format that can detect attomole-range hapten molecules. We selected 11-deoxycortisol (11-DC; Mr...
6.
Kotoshiba S, Nakayama K
Nihon Rinsho
. 2005 Nov;
63(11):2047-56.
PMID: 16277271
The cell cycle of eukaryotic cells is regulated by a series of protein complexes composed of cyclins and cyclin-dependent kinases (CDKs), the activity of which is suppressed by a group...
7.
Hara T, Kamura T, Kotoshiba S, Takahashi H, Fujiwara K, Onoyama I, et al.
Mol Cell Biol
. 2005 Oct;
25(21):9292-303.
PMID: 16227581
KPC2 (Kip1 ubiquitylation-promoting complex 2) together with KPC1 forms the ubiquitin ligase KPC, which regulates degradation of the cyclin-dependent kinase inhibitor p27 at the G(1) phase of the cell cycle....
8.
Kotoshiba S, Kamura T, Hara T, Ishida N, Nakayama K
J Biol Chem
. 2005 Mar;
280(18):17694-700.
PMID: 15746103
The cyclin-dependent kinase (CDK) inhibitor p27 is degraded at the G(0)-G(1) transition of the cell cycle by the ubiquitin-proteasome pathway in a Skp2-independent manner. We recently identified a novel ubiquitin...
9.
Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway R, et al.
Genes Dev
. 2004 Dec;
18(24):3055-65.
PMID: 15601820
The ECS (Elongin B/C-Cul2/Cul5-SOCS-box protein) complex is a member of a family of ubiquitin ligases that share a Cullin-Rbx module. SOCS-box proteins recruit substrates to the ECS complex and are...
10.
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, et al.
Proc Natl Acad Sci U S A
. 2003 Aug;
100(18):10231-6.
PMID: 12925736
The abundance of the cyclin-dependent kinase (CDK) inhibitor p57Kip2, an important regulator of cell cycle progression, is thought to be controlled by the ubiquitin-proteasome pathway. The Skp1/Cul1/F-box (SCF)-type E3 ubiquitin...