Philipp Kaldis
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Explore the profile of Philipp Kaldis including associated specialties, affiliations and a list of published articles.
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Articles
124
Citations
4555
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Recent Articles
1.
Keles U, Kalem-Yapar N, Hulten H, Zhao L, Kaldis P
Mol Cell Biol
. 2024 Dec;
45(2):47-58.
PMID: 39726368
Complex metabolic diseases due to overnutrition such as obesity, type 2 diabetes, and fatty liver disease are a major burden on the healthcare system worldwide. Current research primarily focuses on...
2.
Kaldis P, Porter L
Front Cell Dev Biol
. 2024 Aug;
12:1458895.
PMID: 39211389
Protein homeostasis depends on many fundamental processes including mRNA synthesis, translation, post-translational modifications, and proteolysis. In the late 70s and early 80s the discovery that the small 76 amino acid...
3.
Kaldis P, Zhao L
PLoS One
. 2024 Jan;
19(1):e0293243.
PMID: 38198468
PIWI-interacting RNAs (piRNAs) are important for ensuring the integrity of the germline. 3'-terminal 2'-O-methylation is essential for piRNA maturation and to protect them from degradation. HENMT1 (HEN Methyltransferase 1) carries...
4.
Tanaka T, Miyakoshi Y, Kobayashi Y, Xiaolong S, Daiyang Y, Ochi H, et al.
Adv Biol (Weinh)
. 2023 Jul;
7(12):e2300136.
PMID: 37424388
Osteocytes have recently been identified as a new regulator of bone remodeling, but the detailed mechanism of their differentiation from osteoblasts remains unclear. The purpose of this study is to...
5.
6.
Palmer N, Talib S, Goh C, Biswas K, Sharan S, Kaldis P
PLoS One
. 2023 Mar;
18(3):e0283590.
PMID: 36952545
Cyclin dependent-kinase 2 (CDK2) plays important functions during the mitotic cell cycle and also facilitates several key events during germ cell development. The majority of CDK2's known meiotic functions occur...
7.
Colon-Mesa I, Sainz N, Corrales P, Collantes M, Kaldis P, Martinez J, et al.
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36768986
The aim of this work was to investigate the effect of the whole-body deletion of on the activity of brown adipose tissue and the susceptibility to develop obesity and glucose...
8.
Zhao L, Guccione E, Kaldis P
Int J Mol Sci
. 2023 Jan;
24(2).
PMID: 36674842
The PRDM family of methyltransferases has been implicated in cellular proliferation and differentiation and is deregulated in human diseases, most notably in cancer. PRDMs are related to the SET domain...
9.
Keles U, Ow J, Kuentzel K, Zhao L, Kaldis P
Cell Mol Life Sci
. 2022 Dec;
80(1):4.
PMID: 36477411
Excessive fat accumulation in the liver has become a major health threat worldwide. Unresolved fat deposition in the liver can go undetected until it develops into fatty liver disease, followed...
10.
Zhao L, Kaldis P
PLoS Comput Biol
. 2022 May;
18(5):e1010140.
PMID: 35613161
Methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a new drug target that is expressed in cancer cells but not in normal adult cells, which provides an Achilles heel to selectively kill cancer cells....